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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4qmy STU Serine/threonine-protein kinase 24 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4qmy STUSerine/threonine-protein kinase 24 2.7.11.1 0.953
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.773
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.772
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.771
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.756
4e5i 0N9Polymerase acidic protein / 0.744
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.738
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.737
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.737
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.726
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.724
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.718
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.716
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.715
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.713
3a62 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.708
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.706
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.704
2z2w 770Wee1-like protein kinase 2.7.10.2 0.691
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.688
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.679
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.677
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.675
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.672
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.672
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.668
4fr4 STUSerine/threonine-protein kinase 32A 2.7.11.1 0.667
4wsq KSAAP2-associated protein kinase 1 2.7.11.1 0.663
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.662
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.656