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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4o0r X4Z Serine/threonine-protein kinase PAK 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4o0r X4ZSerine/threonine-protein kinase PAK 1 2.7.11.1 0.930
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2x4z X4ZSerine/threonine-protein kinase PAK 4 2.7.11.1 0.729
2wpa 889Cyclin-dependent kinase 2 2.7.11.22 0.721
4f63 0S7Fibroblast growth factor receptor 1 / 0.700
4ks7 X4ZSerine/threonine-protein kinase PAK 6 2.7.11.1 0.678
4nks 2M2Fibroblast growth factor receptor 1 / 0.669
1vyw 292Cyclin-dependent kinase 2 2.7.11.22 0.661
4bgq 38RCyclin-dependent kinase-like 5 2.7.11.22 0.658
4f65 0S9Fibroblast growth factor receptor 1 / 0.656
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.656
3w16 P9JAurora kinase A 2.7.11.1 0.654
4jbq VX6Aurora kinase A 2.7.11.1 0.654
3lfn A27Cyclin-dependent kinase 2 2.7.11.22 0.652
4f64 0S8Fibroblast growth factor receptor 1 / 0.650