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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4nx7 FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4nx7 FOLDihydrofolate reductase 1.5.1.3 1.065
4nx6 FOLDihydrofolate reductase 1.5.1.3 1.056
4kjj FOLDihydrofolate reductase 1.5.1.3 1.017
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.978
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.953
4x5g FOLDihydrofolate reductase 1.5.1.3 0.948
1dyi FOLDihydrofolate reductase 1.5.1.3 0.946
1dyh DZFDihydrofolate reductase 1.5.1.3 0.925
4x5f FOLDihydrofolate reductase 1.5.1.3 0.921
4i1n FOLDihydrofolate reductase 1.5.1.3 0.909
7dfr FOLDihydrofolate reductase 1.5.1.3 0.906
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.896
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.895
2zza FOLDihydrofolate reductase / 0.895
1dyj DDFDihydrofolate reductase 1.5.1.3 0.894
4fhb FOLDihydrofolate reductase 1.5.1.3 0.872
3tqb FOLDihydrofolate reductase / 0.866
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.856
5ccc DDFDihydrofolate reductase 1.5.1.3 0.850
4i13 FOLDihydrofolate reductase 1.5.1.3 0.849
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.846
4m6k FOLDihydrofolate reductase 1.5.1.3 0.844
1jol FFODihydrofolate reductase 1.5.1.3 0.827
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.821
1re7 FOLDihydrofolate reductase 1.5.1.3 0.819
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.816
4x5h FOLDihydrofolate reductase 1.5.1.3 0.810
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.808
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.799
1hfr MOTDihydrofolate reductase 1.5.1.3 0.797
3dau MTXDihydrofolate reductase 1.5.1.3 0.797
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.796
1jom FFODihydrofolate reductase 1.5.1.3 0.795
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.795
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.793
4kfj FOLDihydrofolate reductase 1.5.1.3 0.792
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.790
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.787
4x5i FOLDihydrofolate reductase 1.5.1.3 0.787
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.783
1dre MTXDihydrofolate reductase 1.5.1.3 0.775
1df7 MTXDihydrofolate reductase 1.5.1.3 0.774
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.774
1tdr MTXDihydrofolate reductase 1.5.1.3 0.774
1dhj MTXDihydrofolate reductase 1.5.1.3 0.771
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.770
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.768
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.766
1drf FOLDihydrofolate reductase 1.5.1.3 0.763
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.756
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.755
4qi9 MTXDihydrofolate reductase / 0.754
1drb MTXDihydrofolate reductase 1.5.1.3 0.753
4dfr MTXDihydrofolate reductase 1.5.1.3 0.753
1dhf FOLDihydrofolate reductase 1.5.1.3 0.752
3dfr MTXDihydrofolate reductase 1.5.1.3 0.752
3tq9 MTXDihydrofolate reductase / 0.750
4p66 MTXDihydrofolate reductase / 0.750
1dhi MTXDihydrofolate reductase 1.5.1.3 0.749
2d0k FOLDihydrofolate reductase 1.5.1.3 0.742
3ghv GHCDihydrofolate reductase 1.5.1.3 0.742
2drc MTXDihydrofolate reductase 1.5.1.3 0.741
4keb FOLDihydrofolate reductase 1.5.1.3 0.740
1dls MTXDihydrofolate reductase 1.5.1.3 0.737
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.735
3frd DHFDihydrofolate reductase 1.5.1.3 0.733
1dra MTXDihydrofolate reductase 1.5.1.3 0.730
3eig MTXDihydrofolate reductase 1.5.1.3 0.727
3och 2MXDihydrofolate reductase 1.5.1.3 0.727
4p68 MTXDihydrofolate reductase / 0.724
1hfp MOTDihydrofolate reductase 1.5.1.3 0.722
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.722
1u72 MTXDihydrofolate reductase 1.5.1.3 0.722
2qk8 MTXDihydrofolate reductase / 0.722
2w3m FOLDihydrofolate reductase 1.5.1.3 0.722
1ohj COPDihydrofolate reductase 1.5.1.3 0.712
3drc MTXDihydrofolate reductase 1.5.1.3 0.708
1ddr MTXDihydrofolate reductase 1.5.1.3 0.701
3ia4 MTXDihydrofolate reductase / 0.700
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.692
4m6l 21VDihydrofolate reductase 1.5.1.3 0.692
5hi6 MTXDihydrofolate reductase / 0.690
4x5j FOLDihydrofolate reductase 1.5.1.3 0.688
1u70 MTXDihydrofolate reductase 1.5.1.3 0.684
3ghw GHWDihydrofolate reductase 1.5.1.3 0.684
1hfq MOTDihydrofolate reductase 1.5.1.3 0.682
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.674
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.673
4eil FOLBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.673
2dhf DZFDihydrofolate reductase 1.5.1.3 0.665
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.664
1e26 GPBDihydrofolate reductase 1.5.1.3 0.651