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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4nx6 FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4nx6 FOLDihydrofolate reductase 1.5.1.3 1.081
4nx7 FOLDihydrofolate reductase 1.5.1.3 1.056
3ql3 FOLDihydrofolate reductase 1.5.1.3 1.016
1rx2 FOLDihydrofolate reductase 1.5.1.3 1.001
4kjj FOLDihydrofolate reductase 1.5.1.3 0.977
4x5g FOLDihydrofolate reductase 1.5.1.3 0.948
4x5f FOLDihydrofolate reductase 1.5.1.3 0.940
1dyh DZFDihydrofolate reductase 1.5.1.3 0.933
1dyi FOLDihydrofolate reductase 1.5.1.3 0.928
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.915
2zza FOLDihydrofolate reductase / 0.914
4i1n FOLDihydrofolate reductase 1.5.1.3 0.913
7dfr FOLDihydrofolate reductase 1.5.1.3 0.902
4fhb FOLDihydrofolate reductase 1.5.1.3 0.897
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.882
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.880
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.880
1dyj DDFDihydrofolate reductase 1.5.1.3 0.869
4m6k FOLDihydrofolate reductase 1.5.1.3 0.854
1re7 FOLDihydrofolate reductase 1.5.1.3 0.853
4i13 FOLDihydrofolate reductase 1.5.1.3 0.846
2w3m FOLDihydrofolate reductase 1.5.1.3 0.844
4kfj FOLDihydrofolate reductase 1.5.1.3 0.837
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.822
5ccc DDFDihydrofolate reductase 1.5.1.3 0.817
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.812
4keb FOLDihydrofolate reductase 1.5.1.3 0.808
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.806
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.804
4x5h FOLDihydrofolate reductase 1.5.1.3 0.803
3tq9 MTXDihydrofolate reductase / 0.799
1jom FFODihydrofolate reductase 1.5.1.3 0.788
3tqb FOLDihydrofolate reductase / 0.784
1dhi MTXDihydrofolate reductase 1.5.1.3 0.781
3ghv GHCDihydrofolate reductase 1.5.1.3 0.780
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.777
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.775
1hfr MOTDihydrofolate reductase 1.5.1.3 0.774
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.774
1jol FFODihydrofolate reductase 1.5.1.3 0.773
1dhf FOLDihydrofolate reductase 1.5.1.3 0.770
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.767
1drf FOLDihydrofolate reductase 1.5.1.3 0.766
1hfq MOTDihydrofolate reductase 1.5.1.3 0.763
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.760
1dre MTXDihydrofolate reductase 1.5.1.3 0.759
3dau MTXDihydrofolate reductase 1.5.1.3 0.759
1drb MTXDihydrofolate reductase 1.5.1.3 0.750
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.749
3frd DHFDihydrofolate reductase 1.5.1.3 0.748
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.746
3dfr MTXDihydrofolate reductase 1.5.1.3 0.743
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.742
4qi9 MTXDihydrofolate reductase / 0.742
5hi6 MTXDihydrofolate reductase / 0.742
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.738
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.737
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.736
3eig MTXDihydrofolate reductase 1.5.1.3 0.736
3och 2MXDihydrofolate reductase 1.5.1.3 0.736
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.734
4p66 MTXDihydrofolate reductase / 0.732
1u72 MTXDihydrofolate reductase 1.5.1.3 0.730
1ohj COPDihydrofolate reductase 1.5.1.3 0.726
2d0k FOLDihydrofolate reductase 1.5.1.3 0.724
3ghw GHWDihydrofolate reductase 1.5.1.3 0.722
1hfp MOTDihydrofolate reductase 1.5.1.3 0.720
1dls MTXDihydrofolate reductase 1.5.1.3 0.719
1tdr MTXDihydrofolate reductase 1.5.1.3 0.719
1df7 MTXDihydrofolate reductase 1.5.1.3 0.718
2drc MTXDihydrofolate reductase 1.5.1.3 0.718
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.717
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.712
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.706
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.705
4x5j FOLDihydrofolate reductase 1.5.1.3 0.701
4eil FOLBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.695
1u70 MTXDihydrofolate reductase 1.5.1.3 0.689
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.687
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.684
1dhj MTXDihydrofolate reductase 1.5.1.3 0.682
4p68 MTXDihydrofolate reductase / 0.682
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.680
2qk8 MTXDihydrofolate reductase / 0.673
3drc MTXDihydrofolate reductase 1.5.1.3 0.673
4x5i FOLDihydrofolate reductase 1.5.1.3 0.669
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.668
3dat MTXDihydrofolate reductase / 0.662
1u5a BIKL-lactate dehydrogenase 1.1.1.27 0.661
1e26 GPBDihydrofolate reductase 1.5.1.3 0.658
1x28 PGUAspartate aminotransferase 2.6.1.1 0.653
2jib TPPOxalyl-CoA decarboxylase 4.1.1.8 0.653
1hbn TP7Methyl-coenzyme M reductase I subunit alpha 2.8.4.1 0.650
1hbn TP7Methyl-coenzyme M reductase I subunit beta 2.8.4.1 0.650
1toj HCIAspartate aminotransferase 2.6.1.1 0.650