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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4nks 2M2 Fibroblast growth factor receptor 1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4nks 2M2Fibroblast growth factor receptor 1 / 1.026
4f65 0S9Fibroblast growth factor receptor 1 / 0.787
4f64 0S8Fibroblast growth factor receptor 1 / 0.772
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4f63 0S7Fibroblast growth factor receptor 1 / 0.714
2xa4 AZ5Tyrosine-protein kinase JAK2 / 0.709
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.699
1vyw 292Cyclin-dependent kinase 2 2.7.11.22 0.698
3i81 EBIInsulin-like growth factor 1 receptor 2.7.10.1 0.697
4nka 2K7Fibroblast growth factor receptor 1 / 0.692
2qhn 582Serine/threonine-protein kinase Chk1 2.7.11.1 0.691
3lfn A27Cyclin-dependent kinase 2 2.7.11.22 0.687
2wpa 889Cyclin-dependent kinase 2 2.7.11.22 0.683
3zmm F9JTyrosine-protein kinase JAK2 / 0.678
2b1p AIZMitogen-activated protein kinase 10 2.7.11.24 0.677
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.675
3tkh 07SSerine/threonine-protein kinase Chk1 2.7.11.1 0.675
2j4z 626Aurora kinase A 2.7.11.1 0.674
2a0c CK9Cyclin-dependent kinase 2 2.7.11.22 0.672
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.671
3nlb 5BESerine/threonine-protein kinase Chk1 2.7.11.1 0.670
4o0r X4ZSerine/threonine-protein kinase PAK 1 2.7.11.1 0.669
4fv8 E63Mitogen-activated protein kinase 1 2.7.11.24 0.667
4nk9 2K5Fibroblast growth factor receptor 1 / 0.665
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.662
3igg EFQCyclin-dependent kinase 2 2.7.11.22 0.661
3ezr EZRCyclin-dependent kinase 2 2.7.11.22 0.660
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.659
2f4j VX6Tyrosine-protein kinase ABL1 2.7.10.2 0.658
3ggf GVDSerine/threonine-protein kinase 26 / 0.658
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.654
3le6 2BZCyclin-dependent kinase 2 2.7.11.22 0.652
4bdh WVISerine/threonine-protein kinase Chk2 2.7.11.1 0.651
4bgq 38RCyclin-dependent kinase-like 5 2.7.11.22 0.651
3e5a VX6Aurora kinase A 2.7.11.1 0.650