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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4mv3 ACP Biotin carboxylase 6.3.4.14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4mv3 ACPBiotin carboxylase 6.3.4.14 0.816
4mv1 ADPBiotin carboxylase 6.3.4.14 0.740
3g8d ADPBiotin carboxylase 6.3.4.14 0.715
4mv4 ACPBiotin carboxylase 6.3.4.14 0.711
1iah ADPTransient receptor potential cation channel subfamily M member 7 2.7.11.1 0.705
3wnz ADPAlanine--anticapsin ligase / 0.702
4zme ADNMyosin heavy chain kinase A 2.7.11.7 0.701
4mv8 ACPBiotin carboxylase 6.3.4.14 0.699
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.688
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.688
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.677
3vpc ADPGlutamate--LysW ligase ArgX 6.3.2 0.677
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.675
3lmh ADPMyosin heavy chain kinase A 2.7.11.7 0.673
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.673
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.673
4ffm ADPUncharacterized protein / 0.667
1px2 ATPSynapsin-1 / 0.665
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.664
2r86 ATP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase / 0.664
2zdg ADPD-alanine--D-alanine ligase / 0.664
1dv2 ATPBiotin carboxylase 6.3.4.14 0.662
3lla ACPMyosin heavy chain kinase A 2.7.11.7 0.662
5jqw ADPN5-carboxyaminoimidazole ribonucleotide synthase / 0.662
1ny3 ADPMAP kinase-activated protein kinase 2 2.7.11.1 0.661
3wo1 ADPAlanine--anticapsin ligase / 0.661
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.660
2r7n ADP5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase / 0.660
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.659
5e9e ANPMyosin heavy chain kinase A 2.7.11.7 0.659
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.657
2vqd AP2Biotin carboxylase 6.3.4.14 0.657
3rv4 ADPBiotin carboxylase 6.3.4.14 0.657
4o30 SAHProbable Histone-lysine N-methyltransferase ATXR5 2.1.1.43 0.657
1ir3 ANPInsulin receptor 2.7.10.1 0.656
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.656
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.656
4o4e ATPKinase / 0.656
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.655
4xgx ADPFAD:protein FMN transferase / 0.655
1ia9 ANPTransient receptor potential cation channel subfamily M member 7 2.7.11.1 0.654
4o4f ATPKinase / 0.654
4dt8 ADNAPH(2'')-Id / 0.653
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.652
2w5b AGSSerine/threonine-protein kinase Nek2 2.7.11.1 0.652
4ffl ADPUncharacterized protein / 0.652
1aux AGSSynapsin-1 / 0.651
4ffr ATPUncharacterized protein / 0.651
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.651
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.650
4ma5 ANPN5-carboxyaminoimidazole ribonucleotide synthase / 0.650