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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4m69 ANP Receptor-interacting serine/threonine-protein kinase 3 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4m69 ANPReceptor-interacting serine/threonine-protein kinase 3 2.7.11.1 1.160
3lmg ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.861
1b38 ATPCyclin-dependent kinase 2 2.7.11.22 0.836
4zse ANPEpidermal growth factor receptor 2.7.10.1 0.820
2vwi ANPSerine/threonine-protein kinase OSR1 2.7.11.1 0.766
1hck ATPCyclin-dependent kinase 2 2.7.11.22 0.756
1b39 ATPCyclin-dependent kinase 2 2.7.11.22 0.732
2gs7 ANPEpidermal growth factor receptor 2.7.10.1 0.728
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.716
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.692
4lv8 ADPRhoptry protein 5 C / 0.690
3q60 ATPRhoptry protein 5B / 0.688
4riy ANPReceptor tyrosine-protein kinase erbB-3 2.7.10.1 0.684
1pvg ANPDNA topoisomerase 2 5.99.1.3 0.683
3kmw ATPIntegrin-linked protein kinase 2.7.11.1 0.683
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.683
1gtr ATPGlutamine--tRNA ligase 6.1.1.18 0.679
4gt3 ATPMitogen-activated protein kinase 1 2.7.11.24 0.679
3ruq ADPChaperonin / 0.678
4coj DTPUncharacterized protein / 0.674
3qyz Z8BMitogen-activated protein kinase 1 2.7.11.24 0.673
1ih8 APCNH(3)-dependent NAD(+) synthetase 6.3.1.5 0.671
3sl2 ATPSensor histidine kinase WalK / 0.670
4col DTPUncharacterized protein / 0.668
4wud ANPDNA gyrase subunit B / 0.667
1qsy DDSDNA polymerase I, thermostable 2.7.7.7 0.666
2pz8 APCNH(3)-dependent NAD(+) synthetase / 0.666
3pls ANPMacrophage-stimulating protein receptor 2.7.10.1 0.663
4xhg ADPUncharacterized protein / 0.662
3akd CDPCytidylate kinase / 0.659
3zkd ANPDNA gyrase subunit B / 0.659
4lv5 ADPRhoptry protein 5B / 0.657
4wuc ANPDNA gyrase subunit B / 0.657
2fsn ADPArchaeal actin homolog / 0.656
2z52 H23Geranylgeranyl pyrophosphate synthase / 0.656
4dtp DGTDNA-directed DNA polymerase / 0.653
1qtq QSIGlutamine--tRNA ligase 6.1.1.18 0.652
3ruv ANPChaperonin / 0.652
4fj5 DTPDNA-directed DNA polymerase / 0.651
4jxx ATPGlutamine--tRNA ligase 6.1.1.18 0.650
4wso NADProbable nicotinate-nucleotide adenylyltransferase / 0.650
4xc0 ACPHeat shock cognate 90 kDa protein / 0.650