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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4lgg VGG Proto-oncogene tyrosine-protein kinase Src 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4lgg VGGProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.913
4lgh 0JNProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.746
4k11 0J9Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.714
1qcf PP1Tyrosine-protein kinase HCK 2.7.10.2 0.708
1qpe PP2Tyrosine-protein kinase Lck 2.7.10.2 0.688
2c0t L3GTyrosine-protein kinase HCK 2.7.10.2 0.674
2ivv PP1Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.674
2c0i L1GTyrosine-protein kinase HCK 2.7.10.2 0.673
2zoq 5IDMitogen-activated protein kinase 3 2.7.11.24 0.671
2zv9 PP2Tyrosine-protein kinase Lyn 2.7.10.2 0.668
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.667
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.667
5f0a 1FBcGMP-dependent protein kinase, putative / 0.664
4e5f 0N7Polymerase acidic protein / 0.660
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.659
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.650