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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4lcj NAD C-terminal-binding protein 2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4lcj NADC-terminal-binding protein 2 / 1.070
2ome NADC-terminal-binding protein 2 / 0.816
2hu2 NADC-terminal binding protein 1 / 0.798
3oet NADErythronate-4-phosphate dehydrogenase / 0.762
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.757
1hku NADC-terminal-binding protein 1 1.1.1 0.749
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.743
2o4c NADErythronate-4-phosphate dehydrogenase / 0.739
4nu6 NADPhosphonate dehydrogenase 1.20.1.1 0.735
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.720
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.719
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.718
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.718
4xrg NADHomospermidine synthase 2.5.1.44 0.715
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.708
4njo NADD-3-phosphoglycerate dehydrogenase, putative / 0.708
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.702
3wv7 ADPHmd co-occurring protein HcgE / 0.696
4k28 NADShikimate dehydrogenase family protein / 0.692
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.691
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.691
1q7g NHOHomoserine dehydrogenase 1.1.1.3 0.690
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.690
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.689
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.688
1dxy NADD-2-hydroxyisocaproate dehydrogenase 1.1.1 0.686
4weq NAPNAD-dependent dehydrogenase / 0.686
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.684
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.684
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.681
3pym NADGlyceraldehyde-3-phosphate dehydrogenase 3 1.2.1.12 0.681
1uxj NADMalate dehydrogenase / 0.679
2gsd NADFormate dehydrogenase / 0.679
3ec7 NADInositol 2-dehydrogenase / 0.679
2vhx NADAlanine dehydrogenase 1.4.1.1 0.677
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.677
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.676
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.675
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.675
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.673
5a1t NAIL-lactate dehydrogenase / 0.673
4jk3 NADUncharacterized protein / 0.672
3nt4 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.671
1cer NADGlyceraldehyde-3-phosphate dehydrogenase / 0.670
1ur5 NADMalate dehydrogenase / 0.670
1j49 NADD-lactate dehydrogenase 1.1.1.28 0.669
3ids NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.669
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.668
2dc1 NADProbable L-aspartate dehydrogenase / 0.668
4k9d NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.666
4plp NADHomospermidine synthase 2.5.1.44 0.666
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.665
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.665
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.664
3wle NAD(R)-specific carbonyl reductase / 0.664
2dfv NADL-threonine 3-dehydrogenase / 0.663
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.663
3d64 NADAdenosylhomocysteinase / 0.663
4jbi NDPAlcohol dehydrogenase (Zinc) / 0.662
1ie3 NADMalate dehydrogenase / 0.661
1vsv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.661
2x0i NAIMalate dehydrogenase / 0.661
4j49 NADUncharacterized protein / 0.661
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.660
4xb1 NDP319aa long hypothetical homoserine dehydrogenase / 0.660
1c1d NAIPhenylalanine dehydrogenase / 0.659
1ib6 NADMalate dehydrogenase / 0.659
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.659
4jji NADAlcohol dehydrogenase class-3 / 0.659
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.659
5bqf NAPProbable hydroxyacid dehydrogenase protein / 0.659
1dss NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.658
1h2h NADL-aspartate dehydrogenase 1.4.1.21 0.658
2dbz NAPGlyoxylate reductase 1.1.1.26 0.657
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.656
1ywg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.655
4uun NAIL-lactate dehydrogenase / 0.655
1xcb NADRedox-sensing transcriptional repressor Rex / 0.654
2ph5 NADHomospermidine synthase / 0.654
3jyq NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.654
4xqc NADHomospermidine synthase 2.5.1.44 0.654
1nq5 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.653
5doz NDPJamJ / 0.653
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.652
4b7x NAPProbable oxidoreductase / 0.651
3qw2 NADMyo-inositol-1-phosphate synthase (Ino1) / 0.650