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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4l03 NAP Isocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4l03 NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 1.234
4kzo NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 1.046
4l04 NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 1.027
4l06 NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.999
3inm NDPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.987
4umx NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.942
2cmj NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.936
4umy NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.873
2cmv NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.854
2qfx NDPIsocitrate dehydrogenase [NADP], mitochondrial 1.1.1.42 0.843
1xkd NAPIsocitrate dehydrogenase [NADP] / 0.762
2qfv NAPIsocitrate dehydrogenase [NADP], mitochondrial 1.1.1.42 0.758
4aov NAPIsocitrate dehydrogenase [NADP] / 0.745
1t09 NAPIsocitrate dehydrogenase [NADP] cytoplasmic 1.1.1.42 0.742
2fjn 073Tyrosine-protein phosphatase non-receptor type 1 3.1.3.48 0.677
4f7i NAD3-isopropylmalate dehydrogenase 1.1.1.85 0.672
3flk NAITartrate dehydrogenase/decarboxylase 1.1.1.93 0.670
2d1c NAPIsocitrate dehydrogenase [NADP] 1.1.1.42 0.658
4wuo NAD3-isopropylmalate dehydrogenase 1.1.1.85 0.658
3oab DSTGeranyl diphosphate synthase large subunit / 0.655
1wuq 8GTGTP cyclohydrolase 1 / 0.654