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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4kjj FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4kjj FOLDihydrofolate reductase 1.5.1.3 1.064
4nx7 FOLDihydrofolate reductase 1.5.1.3 1.017
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.977
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.948
4x5f FOLDihydrofolate reductase 1.5.1.3 0.940
1dyi FOLDihydrofolate reductase 1.5.1.3 0.924
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.922
1dyh DZFDihydrofolate reductase 1.5.1.3 0.914
4x5g FOLDihydrofolate reductase 1.5.1.3 0.910
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.892
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.864
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.853
1re7 FOLDihydrofolate reductase 1.5.1.3 0.849
4i1n FOLDihydrofolate reductase 1.5.1.3 0.848
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.846
4fhb FOLDihydrofolate reductase 1.5.1.3 0.845
7dfr FOLDihydrofolate reductase 1.5.1.3 0.845
4m6k FOLDihydrofolate reductase 1.5.1.3 0.835
4i13 FOLDihydrofolate reductase 1.5.1.3 0.827
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.820
1jom FFODihydrofolate reductase 1.5.1.3 0.818
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.815
3frd DHFDihydrofolate reductase 1.5.1.3 0.806
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.805
2zza FOLDihydrofolate reductase / 0.801
1dyj DDFDihydrofolate reductase 1.5.1.3 0.798
3tqb FOLDihydrofolate reductase / 0.794
4keb FOLDihydrofolate reductase 1.5.1.3 0.793
4x5h FOLDihydrofolate reductase 1.5.1.3 0.788
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.778
4kfj FOLDihydrofolate reductase 1.5.1.3 0.778
5ccc DDFDihydrofolate reductase 1.5.1.3 0.777
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.776
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.773
2w3m FOLDihydrofolate reductase 1.5.1.3 0.772
3dau MTXDihydrofolate reductase 1.5.1.3 0.771
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.770
1tdr MTXDihydrofolate reductase 1.5.1.3 0.770
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.769
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.769
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.767
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.766
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.766
3och 2MXDihydrofolate reductase 1.5.1.3 0.763
1dhj MTXDihydrofolate reductase 1.5.1.3 0.759
2d0k FOLDihydrofolate reductase 1.5.1.3 0.759
1dhf FOLDihydrofolate reductase 1.5.1.3 0.758
1drb MTXDihydrofolate reductase 1.5.1.3 0.751
1jol FFODihydrofolate reductase 1.5.1.3 0.750
3dfr MTXDihydrofolate reductase 1.5.1.3 0.750
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.750
1hfq MOTDihydrofolate reductase 1.5.1.3 0.749
4qi9 MTXDihydrofolate reductase / 0.749
1hfr MOTDihydrofolate reductase 1.5.1.3 0.747
3tq9 MTXDihydrofolate reductase / 0.745
5hi6 MTXDihydrofolate reductase / 0.743
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.741
4p66 MTXDihydrofolate reductase / 0.734
4x5i FOLDihydrofolate reductase 1.5.1.3 0.734
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.732
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.732
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.730
1dra MTXDihydrofolate reductase 1.5.1.3 0.729
1dre MTXDihydrofolate reductase 1.5.1.3 0.724
3eig MTXDihydrofolate reductase 1.5.1.3 0.713
1dhi MTXDihydrofolate reductase 1.5.1.3 0.712
1drf FOLDihydrofolate reductase 1.5.1.3 0.711
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.711
3ghw GHWDihydrofolate reductase 1.5.1.3 0.711
1u72 MTXDihydrofolate reductase 1.5.1.3 0.704
4dfr MTXDihydrofolate reductase 1.5.1.3 0.703
1df7 MTXDihydrofolate reductase 1.5.1.3 0.702
3ia4 MTXDihydrofolate reductase / 0.701
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.697
2qk8 MTXDihydrofolate reductase / 0.690
4p68 MTXDihydrofolate reductase / 0.688
2dhf DZFDihydrofolate reductase 1.5.1.3 0.686
1ddr MTXDihydrofolate reductase 1.5.1.3 0.684
1hfp MOTDihydrofolate reductase 1.5.1.3 0.684
1u70 MTXDihydrofolate reductase 1.5.1.3 0.681
4x5j FOLDihydrofolate reductase 1.5.1.3 0.676
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.674
1dls MTXDihydrofolate reductase 1.5.1.3 0.672
2drc MTXDihydrofolate reductase 1.5.1.3 0.670
4eil FOLBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.670
3drc MTXDihydrofolate reductase 1.5.1.3 0.667
4m6l 21VDihydrofolate reductase 1.5.1.3 0.660
3ghv GHCDihydrofolate reductase 1.5.1.3 0.654
3aej AA5Methionine gamma-lyase / 0.653