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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4juf TPP Benzoylformate decarboxylase 4.1.1.7

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4juf TPPBenzoylformate decarboxylase 4.1.1.7 1.208
4jub TPPBenzoylformate decarboxylase 4.1.1.7 1.175
3fzn D7KBenzoylformate decarboxylase 4.1.1.7 1.171
4k9p TPPBenzoylformate decarboxylase 4.1.1.7 1.112
4ju8 TZDBenzoylformate decarboxylase 4.1.1.7 1.111
4mpr TPPBenzoylformate decarboxylase 4.1.1.7 1.111
3fsj D7KBenzoylformate decarboxylase 4.1.1.7 1.108
1bfd TPPBenzoylformate decarboxylase 4.1.1.7 1.107
4ju9 TZDBenzoylformate decarboxylase 4.1.1.7 1.107
1po7 TZDBenzoylformate decarboxylase 4.1.1.7 1.105
2fwn TDPBenzoylformate decarboxylase 4.1.1.7 1.102
4k9n TZDBenzoylformate decarboxylase 4.1.1.7 1.094
4mq5 TPPBenzoylformate decarboxylase 4.1.1.7 1.086
4qel TZDBenzoylformate decarboxylase 4.1.1.7 1.080
5dgt TZDBenzoylformate decarboxylase 4.1.1.7 1.079
4gm4 TZDBenzoylformate decarboxylase 4.1.1.7 1.069
4k9o TPPBenzoylformate decarboxylase 4.1.1.7 1.059
1mcz TDPBenzoylformate decarboxylase 4.1.1.7 1.056
4mzx TZDBenzoylformate decarboxylase 4.1.1.7 1.050
4gm1 TZDBenzoylformate decarboxylase 4.1.1.7 1.049
2v3w TPPBenzoylformate decarboxylase 4.1.1.7 1.046
4jd5 TZDBenzoylformate decarboxylase 4.1.1.7 1.042
4juc TPPBenzoylformate decarboxylase 4.1.1.7 1.035
4mpp TZDBenzoylformate decarboxylase 4.1.1.7 1.028
4gg1 TZDBenzoylformate decarboxylase 4.1.1.7 0.981
4gm0 TZDBenzoylformate decarboxylase 4.1.1.7 0.921
2w93 TPPPyruvate decarboxylase isozyme 1 / 0.885
2vk8 TPPPyruvate decarboxylase isozyme 1 / 0.879
5c4i TPPOxalate oxidoreductase subunit alpha / 0.843
5c4i TPPOxalate oxidoreductase subunit beta / 0.843
2qta TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.833
5ej5 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.831
4cok TPPPyruvate decarboxylase / 0.825
1umc TDP2-oxoisovalerate dehydrogenase subunit alpha 1.2.4.4 0.822
1umc TDP2-oxoisovalerate dehydrogenase subunit beta 1.2.4.4 0.822
5ej9 TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.821
2q5q TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.816
2q5o TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.814
5esd TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.811
1pyd TDPPyruvate decarboxylase isozyme 1 / 0.807
1ovm TPPIndole-3-pyruvate decarboxylase 4.1.1.74 0.805
2x7j TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.802
3lq4 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.801
5ej4 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.800
1ols TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.798
5ej7 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.797
3oe1 TDLPyruvate decarboxylase 4.1.1.1 0.795
2vk4 TPPPyruvate decarboxylase 4.1.1.1 0.792
3lq2 TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.792
1pvd TPPPyruvate decarboxylase isozyme 1 / 0.784
1jsc TPPAcetolactate synthase catalytic subunit, mitochondrial 2.2.1.6 0.783
2uza HTLPyruvate synthase / 0.780
5eja TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.780
2c31 TZDOxalyl-CoA decarboxylase 4.1.1.8 0.779
3hwx TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.779
2pan TDPGlyoxylate carboligase 4.1.1.47 0.774
4zp1 TPPPyruvate decarboxylase 4.1.1.1 0.771
5ej8 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.769
1l8a TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.764
1pox TPPPyruvate oxidase 1.2.3.3 0.764
2jla TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.764
5eso TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.760
5ej6 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.757
3exh TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.754
3exh TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.754
3iae D7KBenzaldehyde lyase / 0.748
2jlc TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.744
1pow TPPPyruvate oxidase 1.2.3.3 0.741
1y9d TPPPyruvate oxidase 1.2.3.3 0.741
2g25 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.740
2j9f THV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.740
2j9f THV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 1.2.4.4 0.740
1rp7 TZDPyruvate dehydrogenase E1 component 1.2.4.1 0.739
3d7k D7KBenzaldehyde lyase / 0.736
1w88 TDPPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.732
1w88 TDPPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.732
2o1s TDP1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 0.731
3ey9 TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.729
1itz TPPTransketolase, chloroplastic 2.2.1.1 0.727
2g28 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.726
1ni4 TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.725
1ni4 TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.725
3upt TPPTransketolase / 0.720
5ahk TPPAcetolactate synthase II, large subunit / 0.719
2ihu TP9N(2)-(2-carboxyethyl)arginine synthase / 0.716
2c3u 2TPPyruvate synthase / 0.715
3dv0 TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.713
3dv0 TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.713
1v11 TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.712
2ihv TPPN(2)-(2-carboxyethyl)arginine synthase / 0.712
3zhr TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.709
2ez9 TDKPyruvate oxidase 1.2.3.3 0.707
3zhq TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.707
2ag0 TPPBenzaldehyde lyase / 0.704
1ozh HE3Acetolactate synthase, catabolic 2.2.1.6 0.703
2uz1 TPPBenzaldehyde lyase / 0.703
2r8o T5XTransketolase 1 / 0.702
3m34 TPPTransketolase / 0.701
2ezt TDMPyruvate oxidase 1.2.3.3 0.699
3zhu TD8Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.698
1tkc M6TTransketolase 1 2.2.1.1 0.697
2iea TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.694
3ahi HTLProbable phosphoketolase / 0.693
2c42 TPPPyruvate synthase / 0.692
1ay0 TPPTransketolase 1 2.2.1.1 0.687
1gpu THDTransketolase 1 2.2.1.1 0.686
3rim TPPTransketolase 2.2.1.1 0.685
1upa TPPN(2)-(2-carboxyethyl)arginine synthase / 0.684
3ahj TPPProbable phosphoketolase / 0.684
3m6l TPPTransketolase / 0.684
4c7x TPPTransketolase / 0.683
2c3o TPPPyruvate synthase / 0.682
3exf TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.682
3exf TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.682
3m7i TPPTransketolase / 0.682
1ngs TPPTransketolase 1 2.2.1.1 0.681
5exd TPPOxalate oxidoreductase subunit alpha / 0.681
5exd TPPOxalate oxidoreductase subunit beta / 0.681
3zhs TD6Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.679
2ji9 TPWOxalyl-CoA decarboxylase 4.1.1.8 0.677
3ahe THDProbable phosphoketolase / 0.676
4qpz TPPBenzaldehyde lyase / 0.676
2c3y HTLPyruvate synthase / 0.674
2r8p T6FTransketolase 1 / 0.674
3eya TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.671
3zhv TDWMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.670
3zht TD9Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.669
3dva TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.666
3dva TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.666
2ag1 TPPBenzaldehyde lyase / 0.665
2qtc TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.662
3iaf TPPBenzaldehyde lyase / 0.662
1tkb N1TTransketolase 1 2.2.1.1 0.658
4mkf AP5Adenylate kinase / 0.656