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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ixf IXF Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ixf IXFDihydrofolate reductase 1.5.1.3 0.984
4ixg IXGDihydrofolate reductase 1.5.1.3 0.774
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
1e26 GPBDihydrofolate reductase 1.5.1.3 0.665
3qly 55VUncharacterized protein / 0.663
4p66 MTXDihydrofolate reductase / 0.663
1hfp MOTDihydrofolate reductase 1.5.1.3 0.661
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.661
1hfr MOTDihydrofolate reductase 1.5.1.3 0.658
3kjs DQ1Bifunctional dihydrofolate reductase-thymidylate synthase / 0.656
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.655
2blb CP7Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.654
3jwm 5WBDihydrofolate reductase / 0.654
2w3w VG9Dihydrofolate reductase / 0.651
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.650
4fhb FOLDihydrofolate reductase 1.5.1.3 0.650
4p68 MTXDihydrofolate reductase / 0.650