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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4iw6 1GU Estrogen receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4iw6 1GUEstrogen receptor / 1.141
4iu7 1GMEstrogen receptor / 0.997
4ivw 1GJEstrogen receptor / 0.889
4iv2 1GREstrogen receptor / 0.820
1xpc AITEstrogen receptor / 0.795
4iv4 1GSEstrogen receptor / 0.785
2bj4 OHTEstrogen receptor / 0.782
1xp6 AIUEstrogen receptor / 0.776
3ert OHTEstrogen receptor / 0.770
2qe4 JJ3Estrogen receptor / 0.760
1yim CM4Estrogen receptor / 0.744
1xp9 AIJEstrogen receptor / 0.742
1yin CM3Estrogen receptor / 0.742
1err RALEstrogen receptor / 0.739
2ayr L4GEstrogen receptor / 0.738
1uom PTIEstrogen receptor / 0.730
1qkm GENEstrogen receptor beta / 0.724
1yy4 4NAEstrogen receptor beta / 0.721
4pp6 STLEstrogen receptor / 0.721
1xp1 AIHEstrogen receptor / 0.718
1x7j GENEstrogen receptor beta / 0.715
1x7b 041Estrogen receptor beta / 0.686
2ouz C3DEstrogen receptor / 0.680
1u3r 338Estrogen receptor beta / 0.679
1x76 697Estrogen receptor beta / 0.676
4zn7 DESEstrogen receptor / 0.673
4e5l DBHPolymerase acidic protein / 0.669
4e5f 0N7Polymerase acidic protein / 0.666
1sj0 E4DEstrogen receptor / 0.665
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
1u9e 397Estrogen receptor beta / 0.658
1qkn RALEstrogen receptor beta / 0.656
2qa8 GENEstrogen receptor / 0.655