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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4hzt 0ZA Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4hzt 0ZABeta-secretase 1 3.4.23.46 0.999
4i0f 1BFBeta-secretase 1 3.4.23.46 0.865
4i0z 1BBBeta-secretase 1 3.4.23.46 0.860
4i11 1CHBeta-secretase 1 3.4.23.46 0.801
4i10 1BSBeta-secretase 1 3.4.23.46 0.756
4i1c 1BEBeta-secretase 1 3.4.23.46 0.717
4i12 1BCBeta-secretase 1 3.4.23.46 0.695