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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4h0u UMP Thymidylate synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4h0u UMPThymidylate synthase / 1.036
4isk UMPThymidylate synthase / 0.923
4ein NOHThymidylate synthase 2.1.1.45 0.900
3qj7 UMPThymidylate synthase ThyA / 0.880
4eb4 UMPThymidylate synthase 2.1.1.45 0.871
4dpd UMPBifunctional dihydrofolate reductase-thymidylate synthase / 0.870
4eil UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.864
1f28 UMPThymidylate synthase 2.1.1.45 0.862
2fto TMPThymidylate synthase / 0.848
4iqq UMPThymidylate synthase / 0.842
4e5o UMPThymidylate synthase 2.1.1.45 0.841
4dq1 UMPThymidylate synthase / 0.831
2vet UMPThymidylate synthase / 0.816
4irr UMPThymidylate synthase / 0.815
3dga UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.812
5by6 UMPThymidylate synthase / 0.809
1b5e DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.803
1j3j UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.787
1b5d DCMDeoxycytidylate 5-hydroxymethyltransferase 2.1.2.8 0.786
4fox UMPThymidylate synthase ThyA / 0.780
3bgx TMPThymidylate synthase / 0.776
1tys TMPThymidylate synthase / 0.771
1bid UMPThymidylate synthase / 0.764
2tsr UMPThymidylate synthase 2.1.1.45 0.747
1vza UMPThymidylate synthase / 0.726
1ddu DDUThymidylate synthase / 0.722
1tdu DURThymidylate synthase / 0.718
1vzb UMPThymidylate synthase / 0.714
1bdu DURThymidylate synthase / 0.712
1jmf UMPThymidylate synthase / 0.709
3dg8 UMPBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.704
2g8a UMPThymidylate synthase / 0.703
1ci7 UMPThymidylate synthase 2.1.1.45 0.692
1ipe NDPTropinone reductase 2 1.1.1.236 0.687
1bp6 UMPThymidylate synthase / 0.682
1tsx UMPThymidylate synthase / 0.678
1tsy UMPThymidylate synthase / 0.676
2wba NDPTrypanothione reductase 1.8.1.12 0.672
1bp0 UMPThymidylate synthase / 0.669
1jmi UMPThymidylate synthase / 0.668
1njc DCMThymidylate synthase / 0.665
1mo9 KPC2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.662
1jmh UMPThymidylate synthase / 0.660
2g86 UMPThymidylate synthase / 0.659
2tdm UMPThymidylate synthase / 0.658
2vwq NAPGlucose 1-dehydrogenase / 0.656
3dk4 NDPGlutathione reductase, mitochondrial 1.8.1.7 0.656
1al7 HSTPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.653