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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4gv1 0XZ RAC-alpha serine/threonine-protein kinase 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4gv1 0XZRAC-alpha serine/threonine-protein kinase 2.7.11.1 1.030
3cqw CQWRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.778
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4oti MI1Serine/threonine-protein kinase N1 / 0.707
3mv5 XFERAC-alpha serine/threonine-protein kinase 2.7.11.1 0.694
4i5c C5ITyrosine-protein kinase JAK1 / 0.682
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.678
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.676
4ekl 0RFRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.669
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.667
4e5f 0N7Polymerase acidic protein / 0.660
3mvh WFERAC-alpha serine/threonine-protein kinase 2.7.11.1 0.658
4axa RKDcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
4j97 ACPFibroblast growth factor receptor 2 / 0.658
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
2vo3 M04cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
3ori AGSSerine/threonine protein kinase / 0.654
1u54 ACPActivated CDC42 kinase 1 / 0.651
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.651
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.650
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.650