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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ftt 6HK Serine/threonine-protein kinase Chk1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ftt 6HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.892
4ftr 5HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.836
4ft0 HK9Serine/threonine-protein kinase Chk1 2.7.11.1 0.825
4ftu 7HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.793
4gh2 HK0Serine/threonine-protein kinase Chk1 2.7.11.1 0.787
4fsy HK7Serine/threonine-protein kinase Chk1 2.7.11.1 0.767
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3tkh 07SSerine/threonine-protein kinase Chk1 2.7.11.1 0.719
4fsz HK8Serine/threonine-protein kinase Chk1 2.7.11.1 0.719
4bib IEOMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.718
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.704
1xjd STUProtein kinase C theta type 2.7.11.13 0.686
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.679
3qd3 3Q53-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.679
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.676
3qcq 3Q03-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.675
2x4f 16XMyosin light chain kinase family member 4 2.7.11.1 0.674
4bbe 3O4Tyrosine-protein kinase JAK2 / 0.673
3qcx 3Q23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.670
3qd4 3Q63-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.666
4jbq VX6Aurora kinase A 2.7.11.1 0.665
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.661
4e5f 0N7Polymerase acidic protein / 0.660
1y6a AAZVascular endothelial growth factor receptor 2 2.7.10.1 0.658
1y6b AAXVascular endothelial growth factor receptor 2 2.7.10.1 0.657
3ztx ZTXAurora kinase B-A 2.7.11.1 0.651