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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fkv 61K Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 1.028
4fkw 62KCyclin-dependent kinase 2 2.7.11.22 0.963
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.939
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.929
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.895
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.883
1ke5 LS1Cyclin-dependent kinase 2 2.7.11.22 0.874
1ke9 LS5Cyclin-dependent kinase 2 2.7.11.22 0.858
1ke8 LS4Cyclin-dependent kinase 2 2.7.11.22 0.852
1ke6 LS2Cyclin-dependent kinase 2 2.7.11.22 0.850
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.850
4fkq 42KCyclin-dependent kinase 2 2.7.11.22 0.849
1fvt 106Cyclin-dependent kinase 2 2.7.11.22 0.847
1ke7 LS3Cyclin-dependent kinase 2 2.7.11.22 0.838
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.819
4fx3 60KCyclin-dependent kinase 2 2.7.11.22 0.810
1p2a 5BNCyclin-dependent kinase 2 2.7.11.22 0.802
3py0 SU9Cyclin-dependent kinase 2 2.7.11.22 0.789
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.768
3ezr EZRCyclin-dependent kinase 2 2.7.11.22 0.756
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.756
2bhe BRYCyclin-dependent kinase 2 2.7.11.22 0.744
1gih 1PUCyclin-dependent kinase 2 2.7.11.22 0.737
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.733
1fvv 107Cyclin-dependent kinase 2 2.7.11.22 0.728
3qrt X14Cyclin-dependent kinase 2 2.7.11.22 0.720
3r8p Z46Cyclin-dependent kinase 2 2.7.11.22 0.718
4fkg 4CKCyclin-dependent kinase 2 2.7.11.22 0.715
1gii 1PUCyclin-dependent kinase 2 2.7.11.22 0.711
2w06 FRVCyclin-dependent kinase 2 2.7.11.22 0.709
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.708
2vz6 FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha 2.7.11.17 0.705
3pj8 404Cyclin-dependent kinase 2 2.7.11.22 0.699
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.695
2b55 D31Cyclin-dependent kinase 2 2.7.11.22 0.694
3lfq A28Cyclin-dependent kinase 2 2.7.11.22 0.692
3qql X03Cyclin-dependent kinase 2 2.7.11.22 0.688
2qkr IXMCdc2-like CDK2/CDC28 like protein kinase / 0.684
4ftl H0KSerine/threonine-protein kinase Chk1 2.7.11.1 0.683
4c59 FEFCyclin-G-associated kinase 2.7.11.1 0.681
2r3m SCXCyclin-dependent kinase 2 2.7.11.22 0.678
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.677
4fsn A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.677
2r3l SCWCyclin-dependent kinase 2 2.7.11.22 0.676
4fto 3HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.673
4lyn 1YGCyclin-dependent kinase 2 2.7.11.22 0.673
3igg EFQCyclin-dependent kinase 2 2.7.11.22 0.672
1v0o INRCell division control protein 2 homolog 2.7.11.22 0.670
2vth LZ2Cyclin-dependent kinase 2 2.7.11.22 0.669
3r1y X76Cyclin-dependent kinase 2 2.7.11.22 0.669
4fsq HK3Serine/threonine-protein kinase Chk1 2.7.11.1 0.669
2x2k X2KProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.668
1ckp PVBCyclin-dependent kinase 2 2.7.11.22 0.665
2r3q 5SCCyclin-dependent kinase 2 2.7.11.22 0.665
3bgq VX2Serine/threonine-protein kinase pim-1 2.7.11.1 0.664
4fsu HK5Serine/threonine-protein kinase Chk1 2.7.11.1 0.664
1e9h INRCyclin-dependent kinase 2 2.7.11.22 0.663
4aw5 30KEphrin type-B receptor 4 2.7.10.1 0.660
2r3k SCQCyclin-dependent kinase 2 2.7.11.22 0.658
1w0x OLOCyclin-dependent kinase 2 2.7.11.22 0.657
2y7j B49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 2.7.11.19 0.657
4acm 7YGCyclin-dependent kinase 2 2.7.11.22 0.656
2b52 D42Cyclin-dependent kinase 2 2.7.11.22 0.651
2vtj LZ4Cyclin-dependent kinase 2 2.7.11.22 0.651
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.650