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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fkq 42K Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4fkq 42KCyclin-dependent kinase 2 2.7.11.22 0.968
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.849
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.843
1ke5 LS1Cyclin-dependent kinase 2 2.7.11.22 0.838
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.838
1fvt 106Cyclin-dependent kinase 2 2.7.11.22 0.836
1ke9 LS5Cyclin-dependent kinase 2 2.7.11.22 0.830
4fkt 48KCyclin-dependent kinase 2 2.7.11.22 0.827
4fkw 62KCyclin-dependent kinase 2 2.7.11.22 0.825
1ke6 LS2Cyclin-dependent kinase 2 2.7.11.22 0.808
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.808
1ke7 LS3Cyclin-dependent kinase 2 2.7.11.22 0.795
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.767
4fx3 60KCyclin-dependent kinase 2 2.7.11.22 0.740
1ke8 LS4Cyclin-dependent kinase 2 2.7.11.22 0.735
1fvv 107Cyclin-dependent kinase 2 2.7.11.22 0.734
3py0 SU9Cyclin-dependent kinase 2 2.7.11.22 0.719
3qrt X14Cyclin-dependent kinase 2 2.7.11.22 0.716
3eb0 DRKUncharacterized protein / 0.714
1e9h INRCyclin-dependent kinase 2 2.7.11.22 0.709
2w06 FRVCyclin-dependent kinase 2 2.7.11.22 0.699
2x2l X2LProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.693
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.692
3ezr EZRCyclin-dependent kinase 2 2.7.11.22 0.687
3l9l L9LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.687
2pe0 39Z3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.686
1q41 IXMGlycogen synthase kinase-3 beta 2.7.11.26 0.683
3mtl FEFCyclin-dependent kinase 16 2.7.11.22 0.683
1gii 1PUCyclin-dependent kinase 2 2.7.11.22 0.675
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.671
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.670
4fkg 4CKCyclin-dependent kinase 2 2.7.11.22 0.669
2b52 D42Cyclin-dependent kinase 2 2.7.11.22 0.666
2vtj LZ4Cyclin-dependent kinase 2 2.7.11.22 0.665
4acm 7YGCyclin-dependent kinase 2 2.7.11.22 0.664
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.664
4qmt H1NSerine/threonine-protein kinase 24 2.7.11.1 0.661
2jam J60Calcium/calmodulin-dependent protein kinase type 1G 2.7.11.17 0.660
3sqq 99ZCyclin-dependent kinase 2 2.7.11.22 0.659
4ek6 10KCyclin-dependent kinase 2 2.7.11.22 0.658
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.657
2b55 D31Cyclin-dependent kinase 2 2.7.11.22 0.650
3pj8 404Cyclin-dependent kinase 2 2.7.11.22 0.650