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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fjh DGT DNA-directed DNA polymerase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
4fjh DGTDNA-directed DNA polymerase / 1.160
4fj5 DTPDNA-directed DNA polymerase / 1.153
4m42 ATPDNA-directed DNA polymerase / 1.123
4fjj TTPDNA-directed DNA polymerase / 1.112
4fjm DCPDNA-directed DNA polymerase / 1.110
3ne6 DCPDNA-directed DNA polymerase / 1.109
4dtj TTPDNA-directed DNA polymerase / 1.099
4fk4 DGTDNA-directed DNA polymerase / 1.097
4dtx TTPDNA-directed DNA polymerase / 1.084
4fjl DGTDNA-directed DNA polymerase / 1.082
4dtp DGTDNA-directed DNA polymerase / 1.078
4m3t ATPDNA-directed DNA polymerase / 1.062
4m3x ATPDNA-directed DNA polymerase / 1.062
3lzj CTPDNA-directed DNA polymerase / 1.058
3sup DCPDNA-directed DNA polymerase / 1.056
4khy TTPDNA-directed DNA polymerase / 0.982
4dto DCPDNA-directed DNA polymerase / 0.909
4dtm DCPDNA-directed DNA polymerase / 0.903
4ptf DCPDNA polymerase epsilon catalytic subunit A 2.7.7.7 0.869
3g6x DGTDNA polymerase iota 2.7.7.7 0.832
4dfk 0L5DNA polymerase I, thermostable 2.7.7.7 0.774
3q23 G2PVirion DNA-directed RNA polymerase / 0.772
4rwn APC2'-5'-oligoadenylate synthase 1 2.7.7.84 0.748
4df4 0L3DNA polymerase I, thermostable 2.7.7.7 0.746
3au2 DGTDNA polymerase beta family (X family) / 0.742
4df8 0L4DNA polymerase I, thermostable 2.7.7.7 0.733
3wbz ATPtRNA(His) guanylyltransferase {ECO:0000256|PIRNR:PIRNR028980} / 0.726
4xj4 3ATCyclic GMP-AMP synthase / 0.725
1qsy DDSDNA polymerase I, thermostable 2.7.7.7 0.711
1qtm TTPDNA polymerase I, thermostable 2.7.7.7 0.703
2q66 ATPPoly(A) polymerase 2.7.7.19 0.702
1r89 CTPCCA-adding enzyme 2.7.7.72 0.695
5a2w AGSMitochondrial poly(A) polymerase / 0.691
1cjv DADAdenylate cyclase type 2 / 0.690
1cjv DADAdenylate cyclase type 5 / 0.690
4u03 GTPCyclic GMP-AMP synthase / 0.680
4xj3 GTPCyclic GMP-AMP synthase / 0.678
5c03 AGSNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.670
2b51 UTPRNA editing complex protein MP57 / 0.669
4tl6 ANPCircadian clock protein kinase KaiC 2.7.11.1 0.667
3ftq GNPSeptin-2 / 0.666
3t3f N5PDNA polymerase I, thermostable 2.7.7.7 0.666
2jlr ANPGenome polyprotein 3.4.21.91 0.665
3w2w ATPCRISPR system Cmr subunit Cmr2 / 0.665
4idn GNPAtlastin-1 3.6.5 0.665
4idp GNPAtlastin-1 3.6.5 0.664
3m0e ATPTranscriptional regulator (NtrC family) / 0.656
4lt6 3ATPoly(A) polymerase gamma 2.7.7.19 0.655
1gir NDPIota toxin component Ia / 0.652
2jj2 ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.652
3fbc TYDNucleoside diphosphate kinase 2.7.4.6 0.651
4k97 ATPCyclic GMP-AMP synthase / 0.651
4fvq ATPTyrosine-protein kinase JAK2 / 0.650