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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fg7 ATP Calcium/calmodulin-dependent protein kinase type 1 2.7.11.17

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.866
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.696
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.695
4dee ADPAurora kinase A 2.7.11.1 0.686
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.682
5dnr ATPAurora kinase A 2.7.11.1 0.680
5l8j ADPAurora kinase A 2.7.11.1 0.680
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.679
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.678
4fg9 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.678
5l8k ADPAurora kinase A 2.7.11.1 0.678
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.677
4jrn ANPRhoptry kinase family protein / 0.675
2pup ADPMethylthioribose kinase 2.7.1.100 0.674
4ceg ADPAurora kinase A 2.7.11.1 0.674
1mq4 ADPAurora kinase A 2.7.11.1 0.673
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.673
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.673
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.672
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.672
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.672
3nie ANPMitogen-activated protein kinase / 0.671
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.671
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.670
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.670
5dn3 ATPAurora kinase A 2.7.11.1 0.669
1ol6 ATPAurora kinase A 2.7.11.1 0.668
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.668
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.667
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.665
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
3qc9 ADPRhodopsin kinase / 0.665
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.664
4o4d ATPKinase / 0.663
1iah ADPTransient receptor potential cation channel subfamily M member 7 2.7.11.1 0.660
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.660
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.658
2pui ADPMethylthioribose kinase 2.7.1.100 0.657
2pzp ACPFibroblast growth factor receptor 2 / 0.657
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.657
3c4z ADPRhodopsin kinase / 0.657
2pul ACPMethylthioribose kinase 2.7.1.100 0.656
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
4mv3 ACPBiotin carboxylase 6.3.4.14 0.656
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
2wqe ADPAurora kinase A 2.7.11.1 0.655
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.655
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.655
3b2t M33Fibroblast growth factor receptor 2 / 0.654
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.654
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
5cu6 ATPCasein kinase II subunit alpha 2.7.11.1 0.653
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.652
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.652
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.651
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.651
3orl AGSSerine/threonine protein kinase / 0.651
2pz5 ACPFibroblast growth factor receptor 2 / 0.650
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.650
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.650
4gv1 0XZRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.650
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.650