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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ej1 FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.933
1dyh DZFDihydrofolate reductase 1.5.1.3 0.882
4x5h FOLDihydrofolate reductase 1.5.1.3 0.865
1dyi FOLDihydrofolate reductase 1.5.1.3 0.859
4i13 FOLDihydrofolate reductase 1.5.1.3 0.856
4kjj FOLDihydrofolate reductase 1.5.1.3 0.853
4x5f FOLDihydrofolate reductase 1.5.1.3 0.851
4x5g FOLDihydrofolate reductase 1.5.1.3 0.849
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.838
4i1n FOLDihydrofolate reductase 1.5.1.3 0.830
1re7 FOLDihydrofolate reductase 1.5.1.3 0.825
4kfj FOLDihydrofolate reductase 1.5.1.3 0.814
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.812
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.812
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.809
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.807
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.804
4m6k FOLDihydrofolate reductase 1.5.1.3 0.800
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.798
4keb FOLDihydrofolate reductase 1.5.1.3 0.794
2w3m FOLDihydrofolate reductase 1.5.1.3 0.790
4fhb FOLDihydrofolate reductase 1.5.1.3 0.789
2d0k FOLDihydrofolate reductase 1.5.1.3 0.787
1dhf FOLDihydrofolate reductase 1.5.1.3 0.786
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.783
1hfq MOTDihydrofolate reductase 1.5.1.3 0.782
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.770
4x5i FOLDihydrofolate reductase 1.5.1.3 0.770
7dfr FOLDihydrofolate reductase 1.5.1.3 0.770
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.768
2zza FOLDihydrofolate reductase / 0.756
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.753
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.751
3tq9 MTXDihydrofolate reductase / 0.750
1hfp MOTDihydrofolate reductase 1.5.1.3 0.749
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.746
3ghw GHWDihydrofolate reductase 1.5.1.3 0.746
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.742
3tqb FOLDihydrofolate reductase / 0.742
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.741
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.740
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.738
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.737
1drf FOLDihydrofolate reductase 1.5.1.3 0.731
4p66 MTXDihydrofolate reductase / 0.731
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.730
4qi9 MTXDihydrofolate reductase / 0.730
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.729
1dyj DDFDihydrofolate reductase 1.5.1.3 0.728
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.728
5ccc DDFDihydrofolate reductase 1.5.1.3 0.728
3dfr MTXDihydrofolate reductase 1.5.1.3 0.723
1ohj COPDihydrofolate reductase 1.5.1.3 0.720
1drb MTXDihydrofolate reductase 1.5.1.3 0.719
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.717
1hfr MOTDihydrofolate reductase 1.5.1.3 0.711
1u70 MTXDihydrofolate reductase 1.5.1.3 0.711
3drc MTXDihydrofolate reductase 1.5.1.3 0.711
1df7 MTXDihydrofolate reductase 1.5.1.3 0.709
1dhj MTXDihydrofolate reductase 1.5.1.3 0.707
3dau MTXDihydrofolate reductase 1.5.1.3 0.706
3och 2MXDihydrofolate reductase 1.5.1.3 0.705
1dre MTXDihydrofolate reductase 1.5.1.3 0.703
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.699
4dfr MTXDihydrofolate reductase 1.5.1.3 0.699
2qk8 MTXDihydrofolate reductase / 0.697
1jom FFODihydrofolate reductase 1.5.1.3 0.696
1ohk COPDihydrofolate reductase 1.5.1.3 0.696
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.696
5hi6 MTXDihydrofolate reductase / 0.696
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.690
4p68 MTXDihydrofolate reductase / 0.688
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.686
1dra MTXDihydrofolate reductase 1.5.1.3 0.685
1jol FFODihydrofolate reductase 1.5.1.3 0.683
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.673
4nhm UN9Prolyl 3,4-dihydroxylase TPA1 1.14.11 0.672
4ij1 17CAnthranilate phosphoribosyltransferase / 0.668
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.666
1drt PCVClavaminate synthase 1 1.14.11.21 0.663
3ghv GHCDihydrofolate reductase 1.5.1.3 0.663
1u72 MTXDihydrofolate reductase 1.5.1.3 0.662
1dhi MTXDihydrofolate reductase 1.5.1.3 0.659
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.659
1e26 GPBDihydrofolate reductase 1.5.1.3 0.658
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.658
2c91 NAPAflatoxin B1 aldehyde reductase member 2 / 0.656
1gir NDPIota toxin component Ia / 0.655
2tsr UMPThymidylate synthase 2.1.1.45 0.655
2drc MTXDihydrofolate reductase 1.5.1.3 0.653
3td8 D2RDihydrofolate reductase 1.5.1.3 0.653
1u5c BIKL-lactate dehydrogenase 1.1.1.27 0.652
1v8l APRADP-ribose pyrophosphatase / 0.652
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.652
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.650