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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4eil CB3 Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4eil CB3Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 1.054
2tsc CB3Thymidylate synthase / 0.759
4ez8 DHFThymidylate synthase 2.1.1.45 0.759
2aaz CB3Thymidylate synthase 2.1.1.45 0.758
4gev CB3Thymidylate synthase / 0.745
1drt PCVClavaminate synthase 1 1.14.11.21 0.744
1g6o ADPCag alpha / 0.744
4a8m ATPRNA-directed RNA polymerase 2.7.7.48 0.744
1kce CB3Thymidylate synthase / 0.726
2fto CB3Thymidylate synthase / 0.724
4knz CB3Thymidylate synthase / 0.724
1aiq CB3Thymidylate synthase / 0.710
1trg CB3Thymidylate synthase / 0.705
1tdu CB3Thymidylate synthase / 0.683
1bq1 CB3Thymidylate synthase / 0.670
4uxj TTPThymidine kinase / 0.660
1zpr CB3Thymidylate synthase / 0.657
1hvy D16Thymidylate synthase 2.1.1.45 0.653
3bhr THGThymidylate synthase / 0.653