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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4eht ADP 2-hydroxyisocaproyl-CoA dehydratase activator

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4eht ADP2-hydroxyisocaproyl-CoA dehydratase activator / 1.073
4ehu ANP2-hydroxyisocaproyl-CoA dehydratase activator / 0.901
1kxp ATPActin, alpha skeletal muscle / 0.860
1t44 ATPActin, alpha skeletal muscle / 0.805
4pkg ATPActin, alpha skeletal muscle / 0.794
4pki ATPActin, alpha skeletal muscle / 0.792
1qz5 ATPActin, alpha skeletal muscle / 0.790
2q36 ATPActin, alpha skeletal muscle / 0.790
1eqy ATPActin, alpha skeletal muscle / 0.786
2zgy GDPPlasmid segregation protein ParM / 0.783
4a62 ANPPlasmid segregation protein ParM / 0.783
1nlv ATPMajor actin / 0.782
1c0f ATPMajor actin / 0.778
4k41 ATPActin, alpha skeletal muscle / 0.776
1s22 ATPActin, alpha skeletal muscle / 0.775
3ffk ATPActin, alpha skeletal muscle / 0.775
4b1v ATPActin, alpha skeletal muscle / 0.772
4pkh ADPActin, alpha skeletal muscle / 0.772
2fsn ADPArchaeal actin homolog / 0.770
3m1f ATPActin, alpha skeletal muscle / 0.767
3eks ATPActin-5C / 0.759
4cbx ATPActin-2 / 0.755
5ce3 ATPActin / 0.755
2zgz GNPPlasmid segregation protein ParM / 0.752
3mn6 ATPActin-5C / 0.750
4jhd ANPActin-5C / 0.748
4a61 ANPPlasmid segregation protein ParM / 0.746
1dej ATPMajor actin / 0.745
3chw ATPMajor actin / 0.744
3m6g ATPActin, alpha skeletal muscle / 0.744
1yxq ATPActin, alpha skeletal muscle / 0.742
3mn9 ATPActin-5C / 0.737
2q97 ATPActin, alpha skeletal muscle / 0.735
1mwm ADPPlasmid segregation protein ParM / 0.733
4m63 ATPActin-5C / 0.731
4b9q ATPChaperone protein DnaK / 0.729
4a2b AGSCell division protein FtsA / 0.725
1rgi ATPActin, alpha skeletal muscle / 0.724
3tu5 ATPActin, alpha skeletal muscle / 0.722
2e2q ADPATP-dependent hexokinase / 0.721
1ijj ATPActin, alpha skeletal muscle / 0.715
4k42 ADPActin, alpha skeletal muscle / 0.710
1atn ATPActin, alpha skeletal muscle / 0.706
4g5q GDPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.706
1mdu ATPActin, alpha skeletal muscle / 0.705
3eku ATPActin-5C / 0.702
1lot ATPActin, alpha skeletal muscle / 0.698
2oan ATPActin, cytoplasmic 1 / 0.698
1rfq ATPActin, alpha skeletal muscle / 0.686
3ll9 ADPIsopentenyl phosphate kinase / 0.683
5f2r ACP78 kDa glucose-regulated protein / 0.683
3cx6 GDPGuanine nucleotide-binding protein subunit alpha-13 / 0.679
4iok ADPFormate--tetrahydrofolate ligase / 0.674
3ule ATPActin-related protein 2 / 0.673
3d2e ATPHeat shock protein homolog SSE1 / 0.671
3tqc ADPPantothenate kinase / 0.669
3hl4 CDCCholine-phosphate cytidylyltransferase A / 0.663
2p9k ATPActin-related protein 2 / 0.662
1wua ATPActin, alpha skeletal muscle / 0.661
1yv5 RISFarnesyl pyrophosphate synthase 2.5.1.10 0.661
4epx GDPGTPase KRas / 0.659
3hzi ATPSerine/threonine-protein kinase toxin HipA / 0.656
4pxz CLRP2Y purinoceptor 12 / 0.656
1hux ADPActivator of (R)-2-hydroxyglutaryl-CoA dehydratase / 0.655
1j0d 5PA1-aminocyclopropane-1-carboxylate deaminase 3.5.99.7 0.655
1zw5 ZOLFarnesyl pyrophosphate synthase 2.5.1.10 0.654
1rqj RISFarnesyl diphosphate synthase 2.5.1.10 0.653
1h8h ATPATP synthase subunit alpha, mitochondrial / 0.652
1h8h ATPATP synthase subunit beta, mitochondrial 3.6.3.14 0.652
3dl0 AP5Adenylate kinase / 0.652
5bsm ATP4-coumarate--CoA ligase 2 6.2.1.12 0.652
4o2l GTPGTP-binding protein Rheb / 0.651
3dkv AP5Adenylate kinase / 0.650