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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4e4m 0NH Tyrosine-protein kinase JAK2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4e4m 0NHTyrosine-protein kinase JAK2 / 0.879
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4f08 1RSTyrosine-protein kinase JAK2 / 0.675
4e4l 0NHTyrosine-protein kinase JAK1 / 0.674
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.665
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.664
4e5f 0N7Polymerase acidic protein / 0.660
2wqe ADPAurora kinase A 2.7.11.1 0.657
2e9p 77ASerine/threonine-protein kinase Chk1 2.7.11.1 0.653
4ivb 1J5Tyrosine-protein kinase JAK1 / 0.651