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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dfr MTX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4dfr MTXDihydrofolate reductase 1.5.1.3 1.111
2drc MTXDihydrofolate reductase 1.5.1.3 1.046
3drc MTXDihydrofolate reductase 1.5.1.3 1.020
1dra MTXDihydrofolate reductase 1.5.1.3 0.996
3och 2MXDihydrofolate reductase 1.5.1.3 0.981
1dhj MTXDihydrofolate reductase 1.5.1.3 0.941
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.940
3dau MTXDihydrofolate reductase 1.5.1.3 0.924
3ia4 MTXDihydrofolate reductase / 0.907
1tdr MTXDihydrofolate reductase 1.5.1.3 0.900
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.895
3tq9 MTXDihydrofolate reductase / 0.889
1dhi MTXDihydrofolate reductase 1.5.1.3 0.888
1df7 MTXDihydrofolate reductase 1.5.1.3 0.878
4p66 MTXDihydrofolate reductase / 0.878
1dls MTXDihydrofolate reductase 1.5.1.3 0.870
3eig MTXDihydrofolate reductase 1.5.1.3 0.867
1drb MTXDihydrofolate reductase 1.5.1.3 0.864
1u70 MTXDihydrofolate reductase 1.5.1.3 0.857
1jol FFODihydrofolate reductase 1.5.1.3 0.855
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.853
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.849
1dre MTXDihydrofolate reductase 1.5.1.3 0.831
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.829
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.825
2zza FOLDihydrofolate reductase / 0.819
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.816
5hi6 MTXDihydrofolate reductase / 0.813
1u72 MTXDihydrofolate reductase 1.5.1.3 0.793
4qi9 MTXDihydrofolate reductase / 0.793
4i1n FOLDihydrofolate reductase 1.5.1.3 0.780
1hfr MOTDihydrofolate reductase 1.5.1.3 0.779
1hfp MOTDihydrofolate reductase 1.5.1.3 0.773
3dfr MTXDihydrofolate reductase 1.5.1.3 0.769
4x5f FOLDihydrofolate reductase 1.5.1.3 0.768
1dyj DDFDihydrofolate reductase 1.5.1.3 0.767
4m6k FOLDihydrofolate reductase 1.5.1.3 0.766
1hfq MOTDihydrofolate reductase 1.5.1.3 0.762
1dds MTXDihydrofolate reductase 1.5.1.3 0.760
4i13 FOLDihydrofolate reductase 1.5.1.3 0.755
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.753
1e26 GPBDihydrofolate reductase 1.5.1.3 0.752
1drf FOLDihydrofolate reductase 1.5.1.3 0.744
1jom FFODihydrofolate reductase 1.5.1.3 0.742
4x5i FOLDihydrofolate reductase 1.5.1.3 0.742
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.741
1ddr MTXDihydrofolate reductase 1.5.1.3 0.740
1dyh DZFDihydrofolate reductase 1.5.1.3 0.738
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.736
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.726
2d0k FOLDihydrofolate reductase 1.5.1.3 0.726
5ccc DDFDihydrofolate reductase 1.5.1.3 0.726
1ohj COPDihydrofolate reductase 1.5.1.3 0.724
1dyi FOLDihydrofolate reductase 1.5.1.3 0.723
4x5g FOLDihydrofolate reductase 1.5.1.3 0.721
2dhf DZFDihydrofolate reductase 1.5.1.3 0.719
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.719
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.716
2w3m FOLDihydrofolate reductase 1.5.1.3 0.714
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.713
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.713
3tqb FOLDihydrofolate reductase / 0.710
3ghw GHWDihydrofolate reductase 1.5.1.3 0.708
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.707
3dat MTXDihydrofolate reductase / 0.707
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.706
4p68 MTXDihydrofolate reductase / 0.705
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.704
4kjj FOLDihydrofolate reductase 1.5.1.3 0.703
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.701
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.700
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.699
4keb FOLDihydrofolate reductase 1.5.1.3 0.699
7dfr FOLDihydrofolate reductase 1.5.1.3 0.698
1hbn TP7Methyl-coenzyme M reductase I subunit alpha 2.8.4.1 0.696
1hbn TP7Methyl-coenzyme M reductase I subunit beta 2.8.4.1 0.696
4x5h FOLDihydrofolate reductase 1.5.1.3 0.696
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.695
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.695
1ohk COPDihydrofolate reductase 1.5.1.3 0.693
4kfj FOLDihydrofolate reductase 1.5.1.3 0.691
1dhf FOLDihydrofolate reductase 1.5.1.3 0.688
1kms LIHDihydrofolate reductase 1.5.1.3 0.685
4fhb FOLDihydrofolate reductase 1.5.1.3 0.676
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.674
1daj MOTDihydrofolate reductase 1.5.1.3 0.672
3frd DHFDihydrofolate reductase 1.5.1.3 0.670
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.670
3td8 D2RDihydrofolate reductase 1.5.1.3 0.669
4m6l 21VDihydrofolate reductase 1.5.1.3 0.669
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.667
3srw Q27Dihydrofolate reductase 1.5.1.3 0.664
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.663
1dyr TOPDihydrofolate reductase 1.5.1.3 0.662
4nhm UN9Prolyl 3,4-dihydroxylase TPA1 1.14.11 0.662
4elf 35IDihydrofolate reductase / 0.661
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.658
3ghv GHCDihydrofolate reductase 1.5.1.3 0.657
2qk8 MTXDihydrofolate reductase / 0.655
1ly4 COQDihydrofolate reductase 1.5.1.3 0.653