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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dea NHI Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4dea NHIAurora kinase A 2.7.11.1 1.056
3uo5 0BXAurora kinase A 2.7.11.1 0.961
2np8 CC3Aurora kinase A 2.7.11.1 0.781
4iwq 1FVSerine/threonine-protein kinase TBK1 2.7.11.1 0.723
5dpv SKEAurora kinase A 2.7.11.1 0.721
5dr6 SKEAurora kinase A 2.7.11.1 0.718
3cjg KIMVascular endothelial growth factor receptor 2 2.7.10.1 0.714
5dr9 SKEAurora kinase A 2.7.11.1 0.712
4bbf O19Tyrosine-protein kinase JAK2 / 0.710
5dt0 SKEAurora kinase A 2.7.11.1 0.696
5ap5 7RODual specificity protein kinase TTK 2.7.12.1 0.691
4d4s BI9Focal adhesion kinase 1 2.7.10.2 0.684
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.683
3cjf SAVVascular endothelial growth factor receptor 2 2.7.10.1 0.683
2x4f 16XMyosin light chain kinase family member 4 2.7.11.1 0.681
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.677
4b6l 9ZPSerine/threonine-protein kinase PLK3 2.7.11.21 0.675
2j9m PY8Cyclin-dependent kinase 2 2.7.11.22 0.673
2wip P49Cyclin-dependent kinase 2 2.7.11.22 0.671
4aqc 88ATyrosine-protein kinase JAK2 / 0.667
4iwo 1H4Serine/threonine-protein kinase TBK1 2.7.11.1 0.667
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.665
4fko 20KCyclin-dependent kinase 2 2.7.11.22 0.663
3ztx ZTXAurora kinase B-A 2.7.11.1 0.661
4grb 0XGCasein kinase II subunit alpha 2.7.11.1 0.661
4j53 1J4Serine/threonine-protein kinase PLK1 2.7.11.21 0.661
2rku R78Serine/threonine-protein kinase PLK1 2.7.11.21 0.660
3nux 3NVCyclin-dependent kinase 6 2.7.11.22 0.660
4e93 GUITyrosine-protein kinase Fes/Fps 2.7.10.2 0.660
1oit HDTCyclin-dependent kinase 2 2.7.11.22 0.659
2c5y MTWCyclin-dependent kinase 2 2.7.11.22 0.658
3et7 349Protein-tyrosine kinase 2-beta 2.7.10.2 0.655
3sw4 18KCyclin-dependent kinase 2 2.7.11.22 0.654
1pxl CK4Cyclin-dependent kinase 2 2.7.11.22 0.653
4im2 BX7Serine/threonine-protein kinase TBK1 2.7.11.1 0.653
1urw I1PCyclin-dependent kinase 2 2.7.11.22 0.652
3fzr 3JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.651
4bbe 3O4Tyrosine-protein kinase JAK2 / 0.650