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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4d4s BI9 Focal adhesion kinase 1 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4d4s BI9Focal adhesion kinase 1 2.7.10.2 1.083
4d58 BI9Focal adhesion kinase 1 2.7.10.2 0.946
2jkk BI9Focal adhesion kinase 1 2.7.10.2 0.800
2jko BIJFocal adhesion kinase 1 2.7.10.2 0.759
4e93 GUITyrosine-protein kinase Fes/Fps 2.7.10.2 0.757
4brx KGWFocal adhesion kinase 1 2.7.10.2 0.752
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.740
4c3f 7KWTyrosine-protein kinase Lck 2.7.10.2 0.694
4jia 1K3Tyrosine-protein kinase JAK2 / 0.689
4dea NHIAurora kinase A 2.7.11.1 0.684
4bbe 3O4Tyrosine-protein kinase JAK2 / 0.681
2yac 937Serine/threonine-protein kinase PLK1 2.7.11.21 0.667
4bgh 3I6Cyclin-dependent kinase 2 2.7.11.22 0.667
3sw7 19KCyclin-dependent kinase 2 2.7.11.22 0.664
4fv4 EK7Mitogen-activated protein kinase 1 2.7.11.24 0.664
4c61 LMMTyrosine-protein kinase JAK2 / 0.663
4hys 1BJMitogen-activated protein kinase 8 2.7.11.24 0.663
2j9m PY8Cyclin-dependent kinase 2 2.7.11.22 0.661
3ama SKEcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4hyu 1BKMitogen-activated protein kinase 8 2.7.11.24 0.661
2hzi JINTyrosine-protein kinase ABL1 2.7.10.2 0.660
2xa4 AZ5Tyrosine-protein kinase JAK2 / 0.660
2xb7 GUIALK tyrosine kinase receptor 2.7.10.1 0.656
4aqc 88ATyrosine-protein kinase JAK2 / 0.655
2euf LQQCyclin-dependent kinase 6 2.7.11.22 0.654
3i60 E86Mitogen-activated protein kinase 1 2.7.11.24 0.652
1oec AA2Fibroblast growth factor receptor 2 / 0.651
4b6l 9ZPSerine/threonine-protein kinase PLK3 2.7.11.21 0.650
4c62 XWWTyrosine-protein kinase JAK2 / 0.650