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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4cd2 FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4cd2 FOLDihydrofolate reductase 1.5.1.3 1.003
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.831
4i13 FOLDihydrofolate reductase 1.5.1.3 0.794
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.776
4i1n FOLDihydrofolate reductase 1.5.1.3 0.774
2d0k FOLDihydrofolate reductase 1.5.1.3 0.773
1df7 MTXDihydrofolate reductase 1.5.1.3 0.764
1e26 GPBDihydrofolate reductase 1.5.1.3 0.763
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.760
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.756
1hfr MOTDihydrofolate reductase 1.5.1.3 0.755
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.754
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.753
3ghv GHCDihydrofolate reductase 1.5.1.3 0.752
1ohj COPDihydrofolate reductase 1.5.1.3 0.746
3dfr MTXDihydrofolate reductase 1.5.1.3 0.742
4dfr MTXDihydrofolate reductase 1.5.1.3 0.741
2drc MTXDihydrofolate reductase 1.5.1.3 0.739
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.738
1dls MTXDihydrofolate reductase 1.5.1.3 0.736
3dau MTXDihydrofolate reductase 1.5.1.3 0.734
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.733
1dre MTXDihydrofolate reductase 1.5.1.3 0.732
4kfj FOLDihydrofolate reductase 1.5.1.3 0.730
1hfq MOTDihydrofolate reductase 1.5.1.3 0.728
4x5g FOLDihydrofolate reductase 1.5.1.3 0.728
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.725
1dra MTXDihydrofolate reductase 1.5.1.3 0.724
1drf FOLDihydrofolate reductase 1.5.1.3 0.724
3tqb FOLDihydrofolate reductase / 0.724
1hfp MOTDihydrofolate reductase 1.5.1.3 0.722
1drb MTXDihydrofolate reductase 1.5.1.3 0.720
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.720
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.718
3drc MTXDihydrofolate reductase 1.5.1.3 0.718
1tdr MTXDihydrofolate reductase 1.5.1.3 0.717
1u70 MTXDihydrofolate reductase 1.5.1.3 0.716
4keb FOLDihydrofolate reductase 1.5.1.3 0.716
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.715
1dyh DZFDihydrofolate reductase 1.5.1.3 0.714
3och 2MXDihydrofolate reductase 1.5.1.3 0.713
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.710
3eig MTXDihydrofolate reductase 1.5.1.3 0.710
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.710
1jom FFODihydrofolate reductase 1.5.1.3 0.708
4x5i FOLDihydrofolate reductase 1.5.1.3 0.708
1u72 MTXDihydrofolate reductase 1.5.1.3 0.707
1dhf FOLDihydrofolate reductase 1.5.1.3 0.706
1dhi MTXDihydrofolate reductase 1.5.1.3 0.705
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.705
1dyi FOLDihydrofolate reductase 1.5.1.3 0.704
5hi6 MTXDihydrofolate reductase / 0.703
1ohk COPDihydrofolate reductase 1.5.1.3 0.702
4qi9 MTXDihydrofolate reductase / 0.700
1dyj DDFDihydrofolate reductase 1.5.1.3 0.699
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.697
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.696
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.696
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.696
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.696
3ghw GHWDihydrofolate reductase 1.5.1.3 0.695
2zza FOLDihydrofolate reductase / 0.692
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.692
4x5f FOLDihydrofolate reductase 1.5.1.3 0.690
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.686
1jol FFODihydrofolate reductase 1.5.1.3 0.682
2dhf DZFDihydrofolate reductase 1.5.1.3 0.678
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.677
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.676
2w3m FOLDihydrofolate reductase 1.5.1.3 0.673
4x5h FOLDihydrofolate reductase 1.5.1.3 0.672
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.668
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.667
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.666
2p1o NLAProtein TRANSPORT INHIBITOR RESPONSE 1 / 0.665
4isu IKMGlutamate receptor 2 / 0.664
3mvy BHZNickel-binding periplasmic protein / 0.659
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.658
1re7 FOLDihydrofolate reductase 1.5.1.3 0.657
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.655
1zha PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.655
3akz GSUGlutamate--tRNA ligase 2 / 0.654
4ie0 PD2Alpha-ketoglutarate-dependent dioxygenase FTO / 0.654
1bp6 UMPThymidylate synthase / 0.653
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.651
3zku HCVIsopenicillin N synthase 1.21.3.1 0.650