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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4c61 LMM Tyrosine-protein kinase JAK2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4c61 LMMTyrosine-protein kinase JAK2 / 0.942
2xa4 AZ5Tyrosine-protein kinase JAK2 / 0.874
4c62 XWWTyrosine-protein kinase JAK2 / 0.786
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4f64 0S8Fibroblast growth factor receptor 1 / 0.710
3w16 P9JAurora kinase A 2.7.11.1 0.709
4f63 0S7Fibroblast growth factor receptor 1 / 0.700
2xyn VX6Abelson tyrosine-protein kinase 2 2.7.10.2 0.683
4nk9 2K5Fibroblast growth factor receptor 1 / 0.677
4aoj V4ZHigh affinity nerve growth factor receptor 2.7.10.1 0.674
4f65 0S9Fibroblast growth factor receptor 1 / 0.673
3w10 RO9Aurora kinase A 2.7.11.1 0.668
3tkh 07SSerine/threonine-protein kinase Chk1 2.7.11.1 0.664
4d4s BI9Focal adhesion kinase 1 2.7.10.2 0.663
3zmm F9JTyrosine-protein kinase JAK2 / 0.660
4e5f 0N7Polymerase acidic protein / 0.660
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.658
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.655
2jc6 QPPCalcium/calmodulin-dependent protein kinase type 1D 2.7.11.17 0.654
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.654