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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4c58 824 Cyclin-G-associated kinase 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4c58 824Cyclin-G-associated kinase 2.7.11.1 1.094
2in6 839Wee1-like protein kinase 2.7.10.2 0.748
2io6 330Wee1-like protein kinase 2.7.10.2 0.727
1xjd STUProtein kinase C theta type 2.7.11.13 0.702
2z2w 770Wee1-like protein kinase 2.7.10.2 0.698
3cqe P91Wee1-like protein kinase 2.7.10.2 0.682
1yhs STUSerine/threonine-protein kinase pim-1 2.7.11.1 0.681
3f69 XDRSerine/threonine-protein kinase PknB 2.7.11.1 0.677
3tku M77Serine/threonine-protein kinase MRCK beta 2.7.11.1 0.676
3zly YSODual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.674
2l1r SXKTroponin C, slow skeletal and cardiac muscles / 0.670
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.669
3bi6 396Wee1-like protein kinase 2.7.10.2 0.662
2gnl H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
4cjk H39Integrase / 0.660
2erz HFScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
3jpv 1DRSerine/threonine-protein kinase pim-1 2.7.11.1 0.658
3fko FKOMitogen-activated protein kinase 14 / 0.656
2r0g 7CKPutative FAD-monooxygenase / 0.654
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.653
4l8m F46Mitogen-activated protein kinase 14 / 0.650