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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bri UNP Ectonucleoside triphosphate diphosphohydrolase I

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bri UNPEctonucleoside triphosphate diphosphohydrolase I / 1.088
4brd ANPEctonucleoside triphosphate diphosphohydrolase I / 0.903
4brg GNPEctonucleoside triphosphate diphosphohydrolase I / 0.892
4ehu ANP2-hydroxyisocaproyl-CoA dehydratase activator / 0.774
4bqz GNPEctonucleoside triphosphate diphosphohydrolase 2 / 0.748
1kxp ATPActin, alpha skeletal muscle / 0.744
4a62 ANPPlasmid segregation protein ParM / 0.738
2q36 ATPActin, alpha skeletal muscle / 0.726
1rgi ATPActin, alpha skeletal muscle / 0.725
4br0 AU1Ectonucleoside triphosphate diphosphohydrolase 2 / 0.719
1dej ATPMajor actin / 0.712
1c0f ATPMajor actin / 0.710
1t44 ATPActin, alpha skeletal muscle / 0.709
3wt0 ATPCell division protein FtsA / 0.709
2a41 ATPActin, alpha skeletal muscle / 0.706
4pki ATPActin, alpha skeletal muscle / 0.704
1qz5 ATPActin, alpha skeletal muscle / 0.703
4k41 ATPActin, alpha skeletal muscle / 0.703
1s22 ATPActin, alpha skeletal muscle / 0.702
1eqy ATPActin, alpha skeletal muscle / 0.701
3d2e ATPHeat shock protein homolog SSE1 / 0.701
4gv8 DUPDUTPase / 0.697
2y6p CTP3-deoxy-manno-octulosonate cytidylyltransferase 2.7.7.38 0.696
1xs4 DCPdCTP deaminase / 0.695
3a5o ATPMajor actin / 0.692
1lot ATPActin, alpha skeletal muscle / 0.691
2cvu ANPRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.691
3mn7 ATPActin-5C / 0.691
3w3d ATPActin, gamma-enteric smooth muscle / 0.688
4pkg ATPActin, alpha skeletal muscle / 0.688
1rfq ATPActin, alpha skeletal muscle / 0.687
1yxq ATPActin, alpha skeletal muscle / 0.687
1mdu ATPActin, alpha skeletal muscle / 0.684
2z52 H23Geranylgeranyl pyrophosphate synthase / 0.683
1atn ATPActin, alpha skeletal muscle / 0.681
3mn9 ATPActin-5C / 0.680
4wrk DUPDUTPase / 0.679
5ce3 ATPActin / 0.675
3ruv ANPChaperonin / 0.673
4cbx ATPActin-2 / 0.673
3m1f ATPActin, alpha skeletal muscle / 0.671
4a61 ANPPlasmid segregation protein ParM / 0.671
4kh0 ATPAspartate carbamoyltransferase regulatory chain {ECO:0000256|HAMAP-Rule:MF_00002} / 0.671
4to4 DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.669
3oab DSTGeranyl diphosphate synthase large subunit / 0.668
4lfv YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.667
3krf DSTGeranyl diphosphate synthase large subunit / 0.666
4h5c YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.666
3m6g ATPActin, alpha skeletal muscle / 0.664
3chw ATPMajor actin / 0.662
4bzb DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.662
5bsm ATP4-coumarate--CoA ligase 2 6.2.1.12 0.661
3ffk ATPActin, alpha skeletal muscle / 0.660
3mzb BHRNickel-binding periplasmic protein / 0.660
3tb9 ANPRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.659
4dxj 0M9Farnesyl pyrophosphate synthase / 0.659
5ao1 DG3Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.658
2o1s TDP1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 0.657
3eks ATPActin-5C / 0.657
3tu5 ATPActin, alpha skeletal muscle / 0.656
2zev B71Geranylgeranyl pyrophosphate synthase / 0.655
3b05 IPEIsopentenyl-diphosphate delta-isomerase / 0.655
4dem YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.655
1khe GCPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.654
3a5m ATPMajor actin / 0.654
4aff ATPNitrogen regulatory protein P-II / 0.653
4jhd ANPActin-5C / 0.653
3ar4 ATPSarcoplasmic/endoplasmic reticulum calcium ATPase 1 3.6.3.8 0.652
4col DTPUncharacterized protein / 0.652
5ej5 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.652
5itz GTPTubulin alpha-1B chain / 0.652
3mvw BHZNickel-binding periplasmic protein / 0.651
4zwg DTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD1 3.1.5 0.651
1lwx AZDNucleoside diphosphate kinase, cytosolic 2.7.4.6 0.650
3myk ANPMyosin-2 heavy chain / 0.650
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.650
3zy3 GDPGDP-fucose protein O-fucosyltransferase 1 2.4.1.221 0.650