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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bie IE6 Mitogen-activated protein kinase kinase kinase 5 2.7.11.25

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bie IE6Mitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.971
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
1nvs UCMSerine/threonine-protein kinase Chk1 2.7.11.1 0.675
3tkh 07SSerine/threonine-protein kinase Chk1 2.7.11.1 0.674
3uli 1N3Cyclin-dependent kinase 2 2.7.11.22 0.670
4jaj XU1Aurora kinase A 2.7.11.1 0.667
5ap5 7RODual specificity protein kinase TTK 2.7.12.1 0.659
2x6d X6DAurora kinase A 2.7.11.1 0.655
4c4g 7RODual specificity protein kinase TTK 2.7.12.1 0.654