Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bib IEO Mitogen-activated protein kinase kinase kinase 5 2.7.11.25

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bib IEOMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.867
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4fsz HK8Serine/threonine-protein kinase Chk1 2.7.11.1 0.730
4ftr 5HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.730
4ft0 HK9Serine/threonine-protein kinase Chk1 2.7.11.1 0.729
4gh2 HK0Serine/threonine-protein kinase Chk1 2.7.11.1 0.729
4fsw HK6Serine/threonine-protein kinase Chk1 2.7.11.1 0.722
4ftt 6HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.718
4ftu 7HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.706
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.695
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.695
3tkh 07SSerine/threonine-protein kinase Chk1 2.7.11.1 0.672
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.667
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4e1z 0MXNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.658
2j0k 4STFocal adhesion kinase 1 2.7.10.2 0.657
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.654
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.653
5dsy UHBPoly [ADP-ribose] polymerase 2 2.4.2.30 0.650