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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4bf2 STU Mitogen-activated protein kinase kinase kinase 5 2.7.11.25

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 1.071
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.922
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.895
1xjd STUProtein kinase C theta type 2.7.11.13 0.874
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 0.859
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.857
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.841
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.816
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.812
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.778
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.767
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.763
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.762
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.761
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.758
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.753
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.749
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.749
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.747
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.745
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3a62 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.736
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.734
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.722
1nvs UCMSerine/threonine-protein kinase Chk1 2.7.11.1 0.718
2hy8 1STSerine/threonine-protein kinase PAK 1 2.7.11.1 0.717
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.717
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.712
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 0.706
1byg STUTyrosine-protein kinase CSK / 0.695
4bib IEOMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.695
2j0k 4STFocal adhesion kinase 1 2.7.10.2 0.689
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.686
4ftr 5HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.685
4ft0 HK9Serine/threonine-protein kinase Chk1 2.7.11.1 0.678
4mvf STUCalcium-dependent protein kinase 2 2.7.11.1 0.677
4ftt 6HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.676
3zew STUEphrin type-B receptor 4 2.7.10.1 0.675
2r0u M54Serine/threonine-protein kinase Chk1 2.7.11.1 0.671
3l8p 0CEAngiopoietin-1 receptor 2.7.10.1 0.671
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.665
3f69 XDRSerine/threonine-protein kinase PknB 2.7.11.1 0.663
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.662
3a60 STURibosomal protein S6 kinase beta-1 2.7.11.1 0.658
4gh2 HK0Serine/threonine-protein kinase Chk1 2.7.11.1 0.654
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.653
4wsq KSAAP2-associated protein kinase 1 2.7.11.1 0.652
3nuy JPZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.651
2gnl H52cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650