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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4b1d 6TG Beta-secretase 1 3.4.23.46

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4b1d 6TGBeta-secretase 1 3.4.23.46 0.964
4b72 2FBBeta-secretase 1 3.4.23.46 0.824
4acx S8ZBeta-secretase 1 3.4.23.46 0.784
4b77 54MBeta-secretase 1 3.4.23.46 0.772
4azy 7F3Beta-secretase 1 3.4.23.46 0.754
4e5i 0N9Polymerase acidic protein / 0.744
4b78 KGGBeta-secretase 1 3.4.23.46 0.739
4b00 I6XBeta-secretase 1 3.4.23.46 0.720
4fri DWABeta-secretase 1 3.4.23.46 0.709
4acu QN7Beta-secretase 1 3.4.23.46 0.706
4b0q GMFBeta-secretase 1 3.4.23.46 0.704
4b1e 6T6Beta-secretase 1 3.4.23.46 0.697
4h3f 10OBeta-secretase 1 3.4.23.46 0.688
4joo 1M4Beta-secretase 1 3.4.23.46 0.688
4b05 32DBeta-secretase 1 3.4.23.46 0.677
4jpc 1M6Beta-secretase 1 3.4.23.46 0.676
4djv 0KMBeta-secretase 1 3.4.23.46 0.675
4djw 0KPBeta-secretase 1 3.4.23.46 0.669
4e5f 0N7Polymerase acidic protein / 0.660
4dju 0KKBeta-secretase 1 3.4.23.46 0.653