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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4aws FMN NADH:flavin oxidoreductase Sye1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4aws FMNNADH:flavin oxidoreductase Sye1 / 1.280
4awt FMNNADH:flavin oxidoreductase Sye1 / 1.209
4b5n FMNNAD(P)H:flavin oxidoreductase Sye4 / 1.088
1vyr FMNPentaerythritol tetranitrate reductase / 1.079
4m5p FMNNADPH dehydrogenase / 1.079
1h63 FMNPentaerythritol tetranitrate reductase / 1.077
3p8i FMNPentaerythritol tetranitrate reductase / 1.075
4h6k FMNNADPH dehydrogenase 1 1.6.99.1 1.074
4k7y FMNNADPH dehydrogenase 1 1.6.99.1 1.074
4rnx FMNNADPH dehydrogenase 1 1.6.99.1 1.073
1h50 FMNPentaerythritol tetranitrate reductase / 1.071
1h51 FMNPentaerythritol tetranitrate reductase / 1.065
3p84 FMNPentaerythritol tetranitrate reductase / 1.056
2abb FMNPentaerythritol tetranitrate reductase / 1.050
1gwj FMNMorphinone reductase / 1.045
3p67 FMNPentaerythritol tetranitrate reductase / 1.044
3f03 FMNPentaerythritol tetranitrate reductase / 1.043
3p8j FMNPentaerythritol tetranitrate reductase / 1.041
3tjl FMNNADPH dehydrogenase / 1.035
4rnw FMNNADPH dehydrogenase 1 1.6.99.1 1.022
1icq FMN12-oxophytodienoate reductase 1 1.3.1.42 1.020
3p62 FMNPentaerythritol tetranitrate reductase / 1.015
1ics FMN12-oxophytodienoate reductase 1 1.3.1.42 1.010
3hgr FMN12-oxophytodienoate reductase 1 1.3.1.42 1.005
1z44 FMNNADPH dehydrogenase / 0.999
1vji FMN12-oxophytodienoate reductase 1 1.3.1.42 0.994
1bwk FMNNADPH dehydrogenase 1 1.6.99.1 0.991
2gou FMNNADH:flavin oxidoreductase Sye1 / 0.991
4tmc FMNOld yellow enzyme / 0.991
3gka FMNN-ethylmaleimide reductase / 0.980
4e2d FMNDehydrogenase / 0.976
4a3u FMNNADH:flavin oxidoreductase/NADH oxidase / 0.972
1bwl FMNNADPH dehydrogenase 1 1.6.99.1 0.966
3p82 FMNPentaerythritol tetranitrate reductase / 0.965
4tmb FMNOld yellow enzyme / 0.964
4df2 FMNNADPH dehydrogenase / 0.956
4e2b FMNDehydrogenase / 0.950
4utm FNRXenobiotic reductase / 0.950
3p74 FMNPentaerythritol tetranitrate reductase / 0.947
3l67 FMNXenobiotic reductase / 0.944
1icp FMN12-oxophytodienoate reductase 1 1.3.1.42 0.939
5cpm FNRNADH:flavin oxidoreductase / 0.924
4utk FNRXenobiotic reductase / 0.923
3n14 FMNXenobiotic reductase / 0.905
2h8x FMNXenA / 0.900
4rnv FMNNADPH dehydrogenase 1 1.6.99.1 0.899
4uth FMNXenobiotic reductase / 0.894
2gqa FMNNADH:flavin oxidoreductase Sye1 / 0.893
4utl FNRXenobiotic reductase / 0.893
4qai FMNNADPH dehydrogenase / 0.892
3l5l FMNXenobiotic reductase / 0.885
2djl FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.878
2hs8 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.877
4wzh FMNDihydroorotate dehydrogenase (fumarate) / 0.871
4qnw FMNChanoclavine-I aldehyde reductase easA / 0.868
1z48 FMNNADPH dehydrogenase / 0.860
3hf3 FMNChromate reductase / 0.859
4ycp FMNtRNA-dihydrouridine(16) synthase / 0.850
1jub FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.847
1jue FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.847
1z41 FMNNADPH dehydrogenase / 0.847
2q3r FMN12-oxophytodienoate reductase 1 1.3.1.42 0.846
1k02 FMNNADPH dehydrogenase 1 1.6.99.1 0.844
4xq6 FMNDihydroorotate dehydrogenase (quinone) / 0.844
4yco FMNtRNA-dihydrouridine(16) synthase / 0.840
3kru FMNNADH:flavin oxidoreductase/NADH oxidase / 0.836
1oya FMNNADPH dehydrogenase 1 1.6.99.1 0.829
2hs6 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.827
2zfa FMNLactate oxidase / 0.817
2hsa FMN12-oxophytodienoate reductase 3 1.3.1.42 0.814
3hgs FMN12-oxophytodienoate reductase 3 1.3.1.42 0.811
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.810
3c3n FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.809
2zru FMNIsopentenyl-diphosphate delta-isomerase / 0.807
1oyc FMNNADPH dehydrogenase 1 1.6.99.1 0.800
3aty FMNProstaglandin F2a synthase / 0.800
4jic FMNGTN Reductase / 0.799
3atz FMNProstaglandin F2a synthase / 0.794
3oix FMNDihydroorotate dehydrogenase / 0.791
1vhn FMNtRNA-dihydrouridine synthase / 0.789
1q45 FMN12-oxophytodienoate reductase 3 1.3.1.42 0.788
3n19 FNRXenobiotic reductase / 0.784
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.783
2nli FMNLactate oxidase / 0.781
2djx FMNDihydroorotate dehydrogenase (fumarate) 1.3.98.1 0.780
1ep3 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.778
4bf9 FMNtRNA-dihydrouridine(16) synthase / 0.760
2j6x FMNLactate oxidase / 0.751
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.750
4rnu FMNNADPH dehydrogenase 1 1.6.99.1 0.747
2zrv FNRIsopentenyl-diphosphate delta-isomerase / 0.735
2du2 FMNLactate oxidase / 0.732
2e77 FMNLactate oxidase / 0.729
2zrz FNRIsopentenyl-diphosphate delta-isomerase / 0.727
3vkj FNRIsopentenyl-diphosphate delta-isomerase / 0.727
4rje FNRLactate oxidase / 0.724
1ep1 FMNDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit 1.3.1.14 0.722
3gye FMNDihydroorotate dehydrogenase (fumarate) / 0.717
2zrx FMNIsopentenyl-diphosphate delta-isomerase / 0.714
1kbj FMNCytochrome b2, mitochondrial 1.1.2.3 0.713
2zry FNRIsopentenyl-diphosphate delta-isomerase / 0.713
4iql FMNEnoyl-(Acyl-carrier-protein) reductase II / 0.706
3gr8 FMNNADPH dehydrogenase / 0.704
1ofd FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.699
2bsl FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.699
4cw5 FMNDfnA / 0.699
1dor FMNDihydroorotate dehydrogenase A (fumarate) 1.3.98.1 0.696
3b05 FNRIsopentenyl-diphosphate delta-isomerase / 0.693
4z9r FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD / 0.692
1kbq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.691
4ef8 FMNDihydroorotate dehydrogenase (fumarate) / 0.691
4ef9 FMNDihydroorotate dehydrogenase (fumarate) / 0.691
1vcf FMNIsopentenyl-diphosphate delta-isomerase / 0.690
1h7w FMNDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.686
2z6i FMN2-nitropropane dioxygenase / 0.683
1szg FNSCytochrome b2, mitochondrial 1.1.2.3 0.682
1dxq FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.681
3ojw FMNNADPH--cytochrome P450 reductase / 0.681
1djq FMNTrimethylamine dehydrogenase 1.5.8.2 0.678
3uwq U5POrotidine 5'-phosphate decarboxylase / 0.673
1qr2 FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.670
2qmy FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.668
3esz FMNFlavodoxin / 0.667
4j8p FMNFlavodoxin / 0.667
3bw4 FMNPutative 2-nitropropane dioxygenase / 0.663
4bmo FMNProtein NrdI / 0.662
4qof FMNRibosyldihydronicotinamide dehydrogenase [quinone] / 0.662
1qcw FNSCytochrome b2, mitochondrial 1.1.2.3 0.661
4qoe FADRibosyldihydronicotinamide dehydrogenase [quinone] / 0.661
1qbg FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.660
2c12 FADNitroalkane oxidase 1.7.3.1 0.660
1amo FMNNADPH--cytochrome P450 reductase / 0.659
1d4a FADNAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.659
1ofe FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.659
2q9u FMNA-type flavoprotein / 0.659
2v0u FMNNPH1-1 / 0.659
3klb FMNUncharacterized protein / 0.659
4bca FADAlkyldihydroxyacetonephosphate synthase, peroxisomal 2.5.1.26 0.659
4hms FMNPhenazine biosynthesis protein PhzG 1.4 0.657
3qfr FMNNADPH--cytochrome P450 reductase / 0.656
1szf FMNCytochrome b2, mitochondrial 1.1.2.3 0.655
2gr3 FADFerredoxin reductase / 0.655
3n3a FMNProtein NrdI / 0.655
4yus FMNFamily 3 adenylate cyclase / 0.655
5ebu FMNLactate oxidase / 0.655
1nb9 RBFRiboflavin kinase 2.7.1.26 0.654
4n65 FMNFMN-dependent NADH-azoreductase 1 / 0.653
1lm1 FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.652
5dju FMNNPH1-2 / 0.652
1llz FMNFerredoxin-dependent glutamate synthase 2 1.4.7.1 0.651
1krh FADBenzoate 1,2-dioxygenase electron transfer component 1.18.1.3 0.650
3bw3 FMNPutative 2-nitropropane dioxygenase / 0.650