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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3zew STU Ephrin type-B receptor 4 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3zew STUEphrin type-B receptor 4 2.7.10.1 0.994
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.915
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.807
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.800
3ckx STUSerine/threonine-protein kinase 24 2.7.11.1 0.797
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.779
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.770
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.748
4e5i 0N9Polymerase acidic protein / 0.744
1qpj STUTyrosine-protein kinase Lck 2.7.10.2 0.741
1xjd STUProtein kinase C theta type 2.7.11.13 0.741
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.733
1byg STUTyrosine-protein kinase CSK / 0.731
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.728
1x8b 824Wee1-like protein kinase 2.7.10.2 0.719
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.719
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.718
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.716
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.714
3a4o STUTyrosine-protein kinase Lyn 2.7.10.2 0.713
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.695
3d7t STUTyrosine-protein kinase CSK / 0.693
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 0.691
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.687
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.675
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.675
1qpd STUTyrosine-protein kinase Lck 2.7.10.2 0.674
5e8w STUTGF-beta receptor type-1 2.7.11.30 0.670
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.669
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.668
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.666
4e5f 0N7Polymerase acidic protein / 0.660
2j0k 4STFocal adhesion kinase 1 2.7.10.2 0.659
5e8y STUTGF-beta receptor type-2 2.7.11.30 0.659
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.655
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.651
1ke8 LS4Cyclin-dependent kinase 2 2.7.11.22 0.650
4acm 7YGCyclin-dependent kinase 2 2.7.11.22 0.650