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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3uzx AOM 3-oxo-5-beta-steroid 4-dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3uzx AOM3-oxo-5-beta-steroid 4-dehydrogenase / 1.111
3uzx AOX3-oxo-5-beta-steroid 4-dehydrogenase / 1.014
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
2j7x ESTEstrogen receptor beta / 0.739
1lho AOMSex hormone-binding globulin / 0.719
4e5l DBHPolymerase acidic protein / 0.719
2pit DHTAndrogen receptor / 0.713
4ofr DHTAndrogen receptor / 0.698
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.696
1t73 DHTAndrogen receptor / 0.694
1t74 DHTAndrogen receptor / 0.693
1xj7 DHTAndrogen receptor / 0.691
2pkl DHTAndrogen receptor / 0.691
4oey DHTAndrogen receptor / 0.689
2pio DHTAndrogen receptor / 0.687
3q95 ESLEstrogen receptor / 0.686
4j6b PLOCytochrome P450 monooxygenase / 0.683
1t5z DHTAndrogen receptor / 0.682
2ocf ESTEstrogen receptor / 0.682
3oll ESTEstrogen receptor beta / 0.682
1t7r DHTAndrogen receptor / 0.681
2ama DHTAndrogen receptor / 0.679
1g50 ESTEstrogen receptor / 0.678
5dx3 ESTEstrogen receptor / 0.676
5hyr ESTEstrogen receptor / 0.674
1gwr ESTEstrogen receptor / 0.672
4pxm ESTEstrogen receptor / 0.671
3nhx ASDSteroid Delta-isomerase 5.3.3.1 0.669
1osv CHCBile acid receptor / 0.666
3nbr ASDSteroid Delta-isomerase 5.3.3.1 0.663
1t63 DHTAndrogen receptor / 0.662
2o4r VD5Vitamin D3 receptor / 0.661
4lxj LANLanosterol 14-alpha demethylase 1.14.13.70 0.659
2g5o DRQEstrogen receptor / 0.658
2w8y 486Progesterone receptor / 0.657
3uud ESTEstrogen receptor / 0.657
1aqu ESTEstrogen sulfotransferase, testis isoform 2.8.2.4 0.656
1t7m DHTAndrogen receptor / 0.654
1d2s DHTSex hormone-binding globulin / 0.653
2pip DHTAndrogen receptor / 0.653
4ofu DHTAndrogen receptor / 0.653
1zhy CLROxysterol-binding protein homolog 4 / 0.652
2aa6 STRMineralocorticoid receptor / 0.651
2aba STRPentaerythritol tetranitrate reductase / 0.651
2q7k TESAndrogen receptor / 0.651
2vdy HCYCorticosteroid-binding globulin / 0.651
1t7f DHTAndrogen receptor / 0.650
1tw4 CHDFatty acid-binding protein, liver / 0.650
2ylp TESAndrogen receptor / 0.650