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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3uli 1N3 Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3uli 1N3Cyclin-dependent kinase 2 2.7.11.22 1.110
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
4fkr 45KCyclin-dependent kinase 2 2.7.11.22 0.729
1ke6 LS2Cyclin-dependent kinase 2 2.7.11.22 0.718
3ezv EZVCyclin-dependent kinase 2 2.7.11.22 0.696
1gii 1PUCyclin-dependent kinase 2 2.7.11.22 0.692
4fks 46KCyclin-dependent kinase 2 2.7.11.22 0.692
1gih 1PUCyclin-dependent kinase 2 2.7.11.22 0.686
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.686
2xnb Y8LCyclin-dependent kinase 2 2.7.11.22 0.686
1y91 CT9Cyclin-dependent kinase 2 2.7.11.22 0.684
4b0g VEKAurora kinase A 2.7.11.1 0.682
2erz HFScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
4im2 BX7Serine/threonine-protein kinase TBK1 2.7.11.1 0.679
2wih P48Cyclin-dependent kinase 2 2.7.11.22 0.676
2x6d X6DAurora kinase A 2.7.11.1 0.674
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.670
3sw4 18KCyclin-dependent kinase 2 2.7.11.22 0.670
4bie IE6Mitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.670
4i5c C5ITyrosine-protein kinase JAK1 / 0.667
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.664
2hzi JINTyrosine-protein kinase ABL1 2.7.10.2 0.663
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.663
1ckp PVBCyclin-dependent kinase 2 2.7.11.22 0.662
4eut BX7Serine/threonine-protein kinase TBK1 2.7.11.1 0.661
4lyn 1YGCyclin-dependent kinase 2 2.7.11.22 0.661
1pxl CK4Cyclin-dependent kinase 2 2.7.11.22 0.660
4fko 20KCyclin-dependent kinase 2 2.7.11.22 0.658
2vn9 GVDCalcium/calmodulin-dependent protein kinase type II subunit delta 2.7.11.17 0.657
2btr U73Cyclin-dependent kinase 2 2.7.11.22 0.656
3tkh 07SSerine/threonine-protein kinase Chk1 2.7.11.1 0.656
3sw7 19KCyclin-dependent kinase 2 2.7.11.22 0.653
1pxp CK8Cyclin-dependent kinase 2 2.7.11.22 0.652
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.652
2r3l SCWCyclin-dependent kinase 2 2.7.11.22 0.650