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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3tti KBI Mitogen-activated protein kinase 10 2.7.11.24

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3tti KBIMitogen-activated protein kinase 10 2.7.11.24 1.175
3ttj JBIMitogen-activated protein kinase 10 2.7.11.24 0.879
2o2u 738Mitogen-activated protein kinase 10 2.7.11.24 0.703
1pmn 984Mitogen-activated protein kinase 10 2.7.11.24 0.683
2gtm LIDMitogen-activated protein kinase 14 / 0.682
5cdt PFBAlcohol dehydrogenase E chain 1.1.1.1 0.679
3fln 3FNMitogen-activated protein kinase 14 / 0.678
3fkn FKNMitogen-activated protein kinase 14 / 0.670
3gc8 B45Mitogen-activated protein kinase 11 2.7.11.24 0.666
3flq 891Mitogen-activated protein kinase 14 / 0.663
2p2h 994Vascular endothelial growth factor receptor 2 2.7.10.1 0.660
1yqj 6NPMitogen-activated protein kinase 14 / 0.658
3fls FLSMitogen-activated protein kinase 14 / 0.658
4l8m F46Mitogen-activated protein kinase 14 / 0.658
2ycf YCFSerine/threonine-protein kinase Chk2 2.7.11.1 0.657
1m7q DQOMitogen-activated protein kinase 14 / 0.656
3c5u P41Mitogen-activated protein kinase 14 / 0.656
3que 3FFMitogen-activated protein kinase 14 / 0.653
4loo SB4Mitogen-activated protein kinase 14 / 0.652
3qlh T27Gag-Pol polyprotein 2.7.7.49 0.651
4xrq 1B0Gag polyprotein / 0.651