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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3tqb FOL Dihydrofolate reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3tqb FOLDihydrofolate reductase / 1.012
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.866
4x5g FOLDihydrofolate reductase 1.5.1.3 0.850
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.837
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.836
1dyh DZFDihydrofolate reductase 1.5.1.3 0.835
4i1n FOLDihydrofolate reductase 1.5.1.3 0.829
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.821
1dyi FOLDihydrofolate reductase 1.5.1.3 0.818
2zza FOLDihydrofolate reductase / 0.816
4m6k FOLDihydrofolate reductase 1.5.1.3 0.810
4x5f FOLDihydrofolate reductase 1.5.1.3 0.805
4x5h FOLDihydrofolate reductase 1.5.1.3 0.802
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.795
4fhb FOLDihydrofolate reductase 1.5.1.3 0.795
4kjj FOLDihydrofolate reductase 1.5.1.3 0.794
1drf FOLDihydrofolate reductase 1.5.1.3 0.786
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.785
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.784
4kfj FOLDihydrofolate reductase 1.5.1.3 0.775
4keb FOLDihydrofolate reductase 1.5.1.3 0.772
4x5i FOLDihydrofolate reductase 1.5.1.3 0.771
7dfr FOLDihydrofolate reductase 1.5.1.3 0.766
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.759
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.756
4i13 FOLDihydrofolate reductase 1.5.1.3 0.755
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.752
1u72 MTXDihydrofolate reductase 1.5.1.3 0.749
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.748
2w3m FOLDihydrofolate reductase 1.5.1.3 0.747
3eig MTXDihydrofolate reductase 1.5.1.3 0.747
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.742
1jom FFODihydrofolate reductase 1.5.1.3 0.738
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.737
1dyj DDFDihydrofolate reductase 1.5.1.3 0.736
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.733
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.732
5ccc DDFDihydrofolate reductase 1.5.1.3 0.732
3ghw GHWDihydrofolate reductase 1.5.1.3 0.731
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.724
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.722
1dra MTXDihydrofolate reductase 1.5.1.3 0.721
1e26 GPBDihydrofolate reductase 1.5.1.3 0.720
5hi6 MTXDihydrofolate reductase / 0.719
1hfq MOTDihydrofolate reductase 1.5.1.3 0.718
3dfr MTXDihydrofolate reductase 1.5.1.3 0.718
2d0k FOLDihydrofolate reductase 1.5.1.3 0.717
1ohk COPDihydrofolate reductase 1.5.1.3 0.716
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.715
1hfp MOTDihydrofolate reductase 1.5.1.3 0.711
4dfr MTXDihydrofolate reductase 1.5.1.3 0.710
1dhf FOLDihydrofolate reductase 1.5.1.3 0.708
2qk8 MTXDihydrofolate reductase / 0.708
1hfr MOTDihydrofolate reductase 1.5.1.3 0.707
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.706
4m6l 21VDihydrofolate reductase 1.5.1.3 0.705
3dau MTXDihydrofolate reductase 1.5.1.3 0.704
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.704
1tdr MTXDihydrofolate reductase 1.5.1.3 0.703
1dre MTXDihydrofolate reductase 1.5.1.3 0.699
4qi9 MTXDihydrofolate reductase / 0.699
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.697
1ohj COPDihydrofolate reductase 1.5.1.3 0.694
1re7 FOLDihydrofolate reductase 1.5.1.3 0.693
4nhm UN9Prolyl 3,4-dihydroxylase TPA1 1.14.11 0.692
2dhf DZFDihydrofolate reductase 1.5.1.3 0.691
2drc MTXDihydrofolate reductase 1.5.1.3 0.691
1u70 MTXDihydrofolate reductase 1.5.1.3 0.689
3tq9 MTXDihydrofolate reductase / 0.689
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.688
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.688
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.685
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.680
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.679
3ia4 MTXDihydrofolate reductase / 0.678
3och 2MXDihydrofolate reductase 1.5.1.3 0.677
4bqy FNTEgl nine homolog 1 / 0.667
1df7 MTXDihydrofolate reductase 1.5.1.3 0.663
1jol FFODihydrofolate reductase 1.5.1.3 0.661
3drc MTXDihydrofolate reductase 1.5.1.3 0.660
2c91 NAPAflatoxin B1 aldehyde reductase member 2 / 0.655
2hu4 G39Neuraminidase / 0.654
4p66 MTXDihydrofolate reductase / 0.654
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.652
1n38 U3HRNA-directed RNA polymerase lambda-3 2.7.7.48 0.651
3dds 26BGlycogen phosphorylase, liver form 2.4.1.1 0.650