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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3sru Q26 Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3sru Q26Dihydrofolate reductase 1.5.1.3 1.199
3srr Q20Dihydrofolate reductase 1.5.1.3 0.876
3sqy Q11Dihydrofolate reductase 1.5.1.3 0.861
3srw Q27Dihydrofolate reductase 1.5.1.3 0.839
4elf 35IDihydrofolate reductase / 0.728
3sr5 Q12Dihydrofolate reductase 1.5.1.3 0.701
2w9h TOPDihydrofolate reductase 1.5.1.3 0.691
3srs M23Dihydrofolate reductase 1.5.1.3 0.684
3fre TOPDihydrofolate reductase 1.5.1.3 0.672
4elb 34SDihydrofolate reductase / 0.672
3srq Q19Dihydrofolate reductase 1.5.1.3 0.669
1dra MTXDihydrofolate reductase 1.5.1.3 0.663
3i8a N22Dihydrofolate reductase 1.5.1.3 0.661
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.660
4e5i 0N9Polymerase acidic protein / 0.660
1e8z STUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2.7.1.153 0.659