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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3s3g TLT Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3s3g TLTAldose reductase 1.1.1.21 0.796
3ghu LDTAldose reductase 1.1.1.21 0.718
3lbo LDTAldose reductase 1.1.1.21 0.717
3m4h 388Aldose reductase 1.1.1.21 0.717
3m64 393Aldose reductase 1.1.1.21 0.703
2inz OHPAldose reductase 1.1.1.21 0.702
2ikj 393Aldose reductase 1.1.1.21 0.701
2pdc 393Aldose reductase 1.1.1.21 0.700
3ght LDTAldose reductase 1.1.1.21 0.700
2pdm ZSTAldose reductase 1.1.1.21 0.699
2iqd LPAAldose reductase 1.1.1.21 0.696
3ld5 LDTAldose reductase 1.1.1.21 0.692
3ghr LDTAldose reductase 1.1.1.21 0.682
3ghs LDTAldose reductase 1.1.1.21 0.682
1us0 LDTAldose reductase 1.1.1.21 0.681
2i16 LDTAldose reductase 1.1.1.21 0.681
2i17 LDTAldose reductase 1.1.1.21 0.681
2qxw LDTAldose reductase 1.1.1.21 0.681
2nvc ITAAldose reductase 1.1.1.21 0.677
3mb9 ZSTAldose reductase 1.1.1.21 0.673
2iki 388Aldose reductase 1.1.1.21 0.671
2pzn 393Aldose reductase 1.1.1.21 0.666
3mc5 393Aldose reductase 1.1.1.21 0.666
3t42 3T4Aldose reductase 1.1.1.21 0.666
2pdi ZSTAldose reductase 1.1.1.21 0.665
2hv5 ZSTAldose reductase 1.1.1.21 0.664
2dv0 ZSTAldose reductase 1.1.1.21 0.663
3lz5 LDTAldose reductase 1.1.1.21 0.663
2pdx ZSTAldose reductase 1.1.1.21 0.662
2duz ZSTAldose reductase 1.1.1.21 0.659