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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3rep ATP Integrin-linked protein kinase 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3rep ATPIntegrin-linked protein kinase 2.7.11.1 1.055
3kmw ATPIntegrin-linked protein kinase 2.7.11.1 0.995
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.741
1b39 ATPCyclin-dependent kinase 2 2.7.11.22 0.722
1pvg ANPDNA topoisomerase 2 5.99.1.3 0.722
4wuc ANPDNA gyrase subunit B / 0.715
3n0z 3ATAdenylate cyclase 2 / 0.706
1hck ATPCyclin-dependent kinase 2 2.7.11.22 0.698
4wud ANPDNA gyrase subunit B / 0.697
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.691
1xjk DGTVitamin B12-dependent ribonucleotide reductase / 0.688
4zse ANPEpidermal growth factor receptor 2.7.10.1 0.685
1b38 ATPCyclin-dependent kinase 2 2.7.11.22 0.683
4xjx ATPType I restriction enzyme EcoR124II R protein 3.1.21.3 0.682
4ivg ANPTNF receptor-associated protein 1 / 0.680
2vwi ANPSerine/threonine-protein kinase OSR1 2.7.11.1 0.678
1zxm ANPDNA topoisomerase 2-alpha 5.99.1.3 0.676
3ork AGSSerine/threonine protein kinase / 0.675
4ipe ANPTNF receptor-associated protein 1 / 0.675
4oi4 ATPmRNA cleavage and polyadenylation factor CLP1 / 0.674
1peq TTPRibonucleoside-diphosphate reductase 2 subunit alpha 1.17.4.1 0.672
1nhh ANPDNA mismatch repair protein MutL / 0.671
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.671
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.666
1jgt APCCarboxyethyl-arginine beta-lactam-synthase 6.3.3.4 0.665
4dem YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.663
2cvv ANPRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.657
2e8u IPEGeranylgeranyl pyrophosphate synthase / 0.656
2oap ANPType II secretion system protein (GspE-2) / 0.656
4c0b ATPmRNA cleavage and polyadenylation factor CLP1 / 0.655
1rqj RISFarnesyl diphosphate synthase 2.5.1.10 0.654
2qta TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.653
1ols TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.652
4r9u ANPVitamin B12 import ATP-binding protein BtuD / 0.652
3tb9 ANPRibonucleoside-diphosphate reductase large chain 1 1.17.4.1 0.651
1xjj DGTVitamin B12-dependent ribonucleotide reductase / 0.650