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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qlg 1N1 Proto-oncogene tyrosine-protein kinase Src 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3qlg 1N1Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 1.113
4xli 1N1Abelson tyrosine-protein kinase 2 2.7.10.2 0.984
3oct 1N1Tyrosine-protein kinase BTK 2.7.10.2 0.890
2zva 1N1Tyrosine-protein kinase Lyn 2.7.10.2 0.880
4xey 1N1Tyrosine-protein kinase ABL1 2.7.10.2 0.869
2gqg 1N1Tyrosine-protein kinase ABL1 2.7.10.2 0.839
2y6o 1N1Ephrin type-A receptor 4 2.7.10.1 0.819
2zyb KSLTyrosine-protein kinase Lck 2.7.10.2 0.778
3lfa 1N1Mitogen-activated protein kinase 14 / 0.769
2zm1 KSFTyrosine-protein kinase Lck 2.7.10.2 0.767
5bvw 1N1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.752
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2hk5 1BMTyrosine-protein kinase HCK 2.7.10.2 0.724
3bx5 304Mitogen-activated protein kinase 14 / 0.712
4eh6 0ONMitogen-activated protein kinase 14 / 0.693
3ocg OCGMitogen-activated protein kinase 14 / 0.676
2vww 7X2Ephrin type-B receptor 4 2.7.10.1 0.672
2zm4 KSMTyrosine-protein kinase Lck 2.7.10.2 0.667
2wot ZZGTGF-beta receptor type-1 2.7.11.30 0.666
4c3f 7KWTyrosine-protein kinase Lck 2.7.10.2 0.664
3gfe P37Mitogen-activated protein kinase 14 / 0.662
4qms 1N1Serine/threonine-protein kinase 24 2.7.11.1 0.661
4e5f 0N7Polymerase acidic protein / 0.660
4gk2 L66Ephrin type-A receptor 3 2.7.10.1 0.658
2gfs PQBMitogen-activated protein kinase 14 / 0.656
4f65 0S9Fibroblast growth factor receptor 1 / 0.655
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.654
3fmm XI2Mitogen-activated protein kinase 14 / 0.653