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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ql3 FOL Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3ql3 FOLDihydrofolate reductase 1.5.1.3 1.070
4nx6 FOLDihydrofolate reductase 1.5.1.3 1.016
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.963
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.953
4x5f FOLDihydrofolate reductase 1.5.1.3 0.940
4kjj FOLDihydrofolate reductase 1.5.1.3 0.922
4x5g FOLDihydrofolate reductase 1.5.1.3 0.919
1dyh DZFDihydrofolate reductase 1.5.1.3 0.899
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.897
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.893
1dyi FOLDihydrofolate reductase 1.5.1.3 0.890
7dfr FOLDihydrofolate reductase 1.5.1.3 0.867
4m6k FOLDihydrofolate reductase 1.5.1.3 0.852
2w3m FOLDihydrofolate reductase 1.5.1.3 0.850
2zza FOLDihydrofolate reductase / 0.847
4i1n FOLDihydrofolate reductase 1.5.1.3 0.837
3tqb FOLDihydrofolate reductase / 0.836
1dyj DDFDihydrofolate reductase 1.5.1.3 0.834
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.829
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.825
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.820
4kfj FOLDihydrofolate reductase 1.5.1.3 0.817
5ccc DDFDihydrofolate reductase 1.5.1.3 0.816
4fhb FOLDihydrofolate reductase 1.5.1.3 0.812
4i13 FOLDihydrofolate reductase 1.5.1.3 0.809
1re7 FOLDihydrofolate reductase 1.5.1.3 0.807
3frd DHFDihydrofolate reductase 1.5.1.3 0.807
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.804
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.800
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.799
3ghw GHWDihydrofolate reductase 1.5.1.3 0.798
5hi6 MTXDihydrofolate reductase / 0.796
1jom FFODihydrofolate reductase 1.5.1.3 0.795
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.793
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.786
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.785
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.783
1dhf FOLDihydrofolate reductase 1.5.1.3 0.781
3ghv GHCDihydrofolate reductase 1.5.1.3 0.781
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.777
1dhi MTXDihydrofolate reductase 1.5.1.3 0.770
1drf FOLDihydrofolate reductase 1.5.1.3 0.769
1tdr MTXDihydrofolate reductase 1.5.1.3 0.769
1hfr MOTDihydrofolate reductase 1.5.1.3 0.765
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.764
1dhj MTXDihydrofolate reductase 1.5.1.3 0.763
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.762
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.762
1dls MTXDihydrofolate reductase 1.5.1.3 0.760
1drb MTXDihydrofolate reductase 1.5.1.3 0.758
4qi9 MTXDihydrofolate reductase / 0.758
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.756
3tq9 MTXDihydrofolate reductase / 0.756
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.755
1df7 MTXDihydrofolate reductase 1.5.1.3 0.754
3dau MTXDihydrofolate reductase 1.5.1.3 0.754
4p66 MTXDihydrofolate reductase / 0.752
1dre MTXDihydrofolate reductase 1.5.1.3 0.751
1hfp MOTDihydrofolate reductase 1.5.1.3 0.751
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.750
3och 2MXDihydrofolate reductase 1.5.1.3 0.750
4x5h FOLDihydrofolate reductase 1.5.1.3 0.750
1e26 GPBDihydrofolate reductase 1.5.1.3 0.746
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.742
4keb FOLDihydrofolate reductase 1.5.1.3 0.741
1hfq MOTDihydrofolate reductase 1.5.1.3 0.739
1jol FFODihydrofolate reductase 1.5.1.3 0.739
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.737
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.737
1u70 MTXDihydrofolate reductase 1.5.1.3 0.737
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.735
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.733
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.724
2qk8 MTXDihydrofolate reductase / 0.721
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.720
1dra MTXDihydrofolate reductase 1.5.1.3 0.719
4dfr MTXDihydrofolate reductase 1.5.1.3 0.719
1ohj COPDihydrofolate reductase 1.5.1.3 0.713
4eil FOLBifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.711
1ohk COPDihydrofolate reductase 1.5.1.3 0.707
3dfr MTXDihydrofolate reductase 1.5.1.3 0.707
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.707
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.707
3ia4 MTXDihydrofolate reductase / 0.704
2d0k FOLDihydrofolate reductase 1.5.1.3 0.701
3drc MTXDihydrofolate reductase 1.5.1.3 0.699
4m6l 21VDihydrofolate reductase 1.5.1.3 0.695
4p68 MTXDihydrofolate reductase / 0.695
1u72 MTXDihydrofolate reductase 1.5.1.3 0.693
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.692
2drc MTXDihydrofolate reductase 1.5.1.3 0.686
4x5i FOLDihydrofolate reductase 1.5.1.3 0.686
2dhf DZFDihydrofolate reductase 1.5.1.3 0.681
4x5j FOLDihydrofolate reductase 1.5.1.3 0.673
3eig MTXDihydrofolate reductase 1.5.1.3 0.669
1ddr MTXDihydrofolate reductase 1.5.1.3 0.666
4nhm UN9Prolyl 3,4-dihydroxylase TPA1 1.14.11 0.662
1dds MTXDihydrofolate reductase 1.5.1.3 0.660
1pd9 CO4Dihydrofolate reductase 1.5.1.3 0.659