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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qd0 3Q4 3-phosphoinositide-dependent protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3qd0 3Q43-phosphoinositide-dependent protein kinase 1 2.7.11.1 1.084
3qcy 3Q33-phosphoinositide-dependent protein kinase 1 2.7.11.1 1.023
3qd4 3Q63-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.980
3qcx 3Q23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.979
3qd3 3Q53-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.961
3qcq 3Q03-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.955
3qcs 3Q13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.934
3nun JMZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.920
3zly YSODual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.687
4fsn A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.683
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.680
3lfn A27Cyclin-dependent kinase 2 2.7.11.22 0.679
3lfs A07Cyclin-dependent kinase 2 2.7.11.22 0.678
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.676
1rej B1LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
3sc1 3S13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.663
2c1a I5ScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.657
1bx6 BA1cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
3nax MP73-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.656
3qql X03Cyclin-dependent kinase 2 2.7.11.22 0.654
3tku M77Serine/threonine-protein kinase MRCK beta 2.7.11.1 0.650