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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3qcy 3Q3 3-phosphoinositide-dependent protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3qcy 3Q33-phosphoinositide-dependent protein kinase 1 2.7.11.1 1.136
3qd0 3Q43-phosphoinositide-dependent protein kinase 1 2.7.11.1 1.023
3qd4 3Q63-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.962
3qcx 3Q23-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.960
3qd3 3Q53-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.958
3qcs 3Q13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.952
3qcq 3Q03-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.935
3nun JMZ3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.934
3zly YSODual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.714
2hog 710Serine/threonine-protein kinase Chk1 2.7.11.1 0.703
3v8s 0HDRho-associated protein kinase 1 2.7.11.1 0.685
2hxl 422Serine/threonine-protein kinase Chk1 2.7.11.1 0.681
4fsn A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.681
3sc1 3S13-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.679
3lfq A28Cyclin-dependent kinase 2 2.7.11.22 0.676
3lfs A07Cyclin-dependent kinase 2 2.7.11.22 0.675
1bx6 BA1cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
3tki S25Serine/threonine-protein kinase Chk1 2.7.11.1 0.671
3w16 P9JAurora kinase A 2.7.11.1 0.670
4nka 2K7Fibroblast growth factor receptor 1 / 0.668
3tkh 07SSerine/threonine-protein kinase Chk1 2.7.11.1 0.661
4f64 0S8Fibroblast growth factor receptor 1 / 0.661
2pe2 4643-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.660
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.659
2c1a I5ScAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.658
2cgx 3D3Serine/threonine-protein kinase Chk1 2.7.11.1 0.657
2pe1 5173-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.657
3zm4 22TDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.657
1rej B1LcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
2clq STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.654
1ydr IQPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
3gnw XNCGenome polyprotein 2.7.7.48 0.650
4ivw 1GJEstrogen receptor / 0.650